Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 5 · 71.4%Very low 2 · 28.6%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Antipsychotic dose increase vs switching the antipsychotic drug

Clinically significant response on global state · non response in schizophrenia

It is very uncertain whether increasing the antipsychotic dose changes global state: Clinically relevant response – as defined by trial… compared with switching the antipsychotic drug (very low certainty).

1 finding from 1 review

Increasing antipsychotic dose versus switching antipsychotic for non response in schizophrenia 2018 · Cochrane Headline outcomes only
RR 1.63 [0.17, 15.99]
1 study · 29 participants
Very low

Antipsychotic dose increase vs switching the antipsychotic drug

Leaving the study early ‐ due to adverse effects (short term) · non response in schizophrenia

1 finding from 1 review

Increasing antipsychotic dose versus switching antipsychotic for non response in schizophrenia 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Antipsychotic dose increase vs switching the antipsychotic drug

Acceptability of treatment ‐ leaving the study early · non response in schizophrenia

1 finding from 1 review

Increasing antipsychotic dose versus switching antipsychotic for non response in schizophrenia 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Antipsychotic dose increase vs switching the antipsychotic drug

Mental state: psychopathology Total endpoint data, BPRS (higher score = worse, scale from: 0‐126) · non response in schizophrenia

1 finding from 1 review

Increasing antipsychotic dose versus switching antipsychotic for non response in schizophrenia 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 29 participants
Very low

Antipsychotic dose increase vs switching the antipsychotic drug

Risk for at least one adverse event per patient · non response in schizophrenia

1 finding from 1 review

Increasing antipsychotic dose versus switching antipsychotic for non response in schizophrenia 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Antipsychotic dose increase vs switching the antipsychotic drug

Service use: 1. Average number of days in hospital per month ‐ by about 24 months · non response in schizophrenia

1 finding from 1 review

Increasing antipsychotic dose versus switching antipsychotic for non response in schizophrenia 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Antipsychotic dose increase vs switching the antipsychotic drug

Average change in quality of life/satisfaction · non response in schizophrenia

1 finding from 1 review

Increasing antipsychotic dose versus switching antipsychotic for non response in schizophrenia 2018 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported