Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

No studies found 2 · 33.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 50%Moderate 1 · 16.7%High 0 · 0%

Cardiovascular mortality · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Amputation · people with critical limb ischaemia

Iloprost showed no clear difference in total amputations compared with PGE1 (low certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 0.89 [0.66, 1.21]
1 study · 209 participants
Low

Quality of life · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Adverse events (participants) · people with critical limb ischaemia

Iloprost probably leads to higher adverse events (participants) compared with PGE1 (moderate certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 2.35 [1.82, 3.04]
4 studies · 511 participants
Moderate

Rest‐pain relief · people with critical limb ischaemia

Iloprost showed no clear difference in rest‐pain relief compared with PGE1 (low certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 1.15 [0.9, 1.47]
1 study · 228 participants
Low

Ulcer healing · people with critical limb ischaemia

Iloprost showed no clear difference in ulcer healing compared with PGE1 (low certainty).

1 finding from 1 review

Prostanoids for critical limb ischaemia 2018 · Cochrane Headline outcomes only
RR 1.24 [0.95, 1.63]
1 study · 228 participants
Low