Findings

What do systematic reviews say?

24 questions · 31 findings · 2 reviews

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No studies found 4 · 12.9%GRADE not reported 0 · 0%Very low 8 · 25.8%Low 16 · 51.6%Moderate 3 · 9.7%High 0 · 0%

IUI in a stimulated cycle vs IUI

Live birth rare per couple (all cycles) · participants with unexplained subfertility

IUI in a stimulated cycle may leads to higher live birth rare per couple (all cycles) compared with IUI (low certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 2.07 [1.22, 3.5]
4 studies · 396 participants
Low

IUI in a stimulated cycle vs IUI

Pregnancy rate per couple (all cycles) · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in pregnancy rate per couple (all cycles) compared with IUI (low certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 6.43 [0.56, 73.35]
1 study · 26 participants
Low

IUI in a stimulated cycle vs TI or expectant management

Live birth rate per couple (all cycles)‐ clomiphene citrate or letrozole · participants with unexplained subfertility

IUI in a stimulated cycle probably leads to higher live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (moderate certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 4.48 [2, 10.01]
1 study · 201 participants
Moderate

IUI in a stimulated cycle vs TI or expectant management

Live birth rate per couple · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (low certainty).

2 findings from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 0.82 [0.45, 1.49]
1 study · 253 participants
Low
Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.59 [0.88, 2.88]
2 studies · 208 participants
Low

IUI in a stimulated cycle vs TI or expectant management

Pregnancy rate · participants with unexplained subfertility

IUI in a stimulated cycle probably leads to higher pregnancy rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (moderate certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 4.68 [2.22, 9.86]
1 study · 201 participants
Moderate

IUI in a stimulated cycle vs TI or expectant management

Pregnancy rate per couple (all cycles) · participants with unexplained subfertility

IUI in a stimulated cycle may leads to higher pregnancy rate per couple (all cycles) compared with TI or expectant management (low certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.69 [1.14, 2.53]
6 studies · 517 participants
Low

IUI in a stimulated cycle vs IUI

Multiple pregnancy rate · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in multiple pregnancy rate per couple compared with IUI (low certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 3 [0.11, 78.27]
1 study · 39 participants
Low

IUI in a stimulated cycle vs IUI

Ovarian Hyperstimulation rate per woman ‐ not measured · participants with unexplained subfertility

The review found no eligible studies for this question.

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

IUI in a stimulated cycle vs IUI

Miscarriage · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in miscarriage rate per couple compared with IUI (low certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 5.21 [0.19, 141.08]
1 study · 26 participants
Low

IUI in a stimulated cycle vs IUI

Ectopic pregnancy rate per couple · participants with unexplained subfertility

It is very uncertain whether IUI in a stimulated cycle changes ectopic pregnancy rate per couple compared with IUI (very low certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 6.48 [0.33, 127.09]
1 study · 211 participants
Very low

IUI in a stimulated cycle vs IUI

Live birth rate per couple · couples with male subfertility

It is very uncertain whether IUI in stimulated cycles changes live birth rate per couple (all cycles) compared with IUI (very low certainty).

1 finding from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 1.34 [0.77, 2.33]
Studies not reported
Very low

IUI in a stimulated cycle vs IUI

Pregnancy rate per couple (all cycles) · couples with male subfertility

It is very uncertain whether IUI in stimulated cycles changes pregnancy rate per couple (all cycles) compared with IUI (very low certainty).

1 finding from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 1.68 [1, 2.82]
Studies not reported
Very low

IUI in a stimulated cycle vs TI or expectant management

Ovarian Hyperstimulation Syndrome rate per woman ‐ not reported · participants with unexplained subfertility

It is very uncertain whether IUI in a stimulated cycle changes ovarian hyperstimulation syndrome rate per woman compared with TI or expectant management (very low certainty).

2 findings from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 2.75 [0.11, 69.83]
1 study · 68 participants
Very low
Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

IUI in a stimulated cycle vs TI or expectant management

Miscarriage · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in miscarriage rate per couple compared with TI or expectant management (low certainty).

2 findings from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.66 [0.56, 4.88]
2 studies · 208 participants
Low
Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 2.87 [1.18, 7.01]
2 studies · 454 participants
Moderate

IUI in a stimulated cycle vs TI or expectant management

Ectopic pregnancy rate per couple · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in ectopic pregnancy rate per couple compared with TI or expectant management (low certainty).

2 findings from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 3.06 [0.12, 76.95]
1 study · 100 participants
Low
Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 9.28 [0.49, 174.6]
1 study · 201 participants
Low

IUI in a stimulated cycle vs TI or expectant management

Multiple pregnancy rate · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in multiple pregnancy rate per couple compared with TI or expectant management (low certainty).

2 findings from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 3.01 [0.47, 19.28]
2 studies · 454 participants
Low
Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.46 [0.55, 3.87]
4 studies · 316 participants
Low

IUI in a stimulated cycle vs TI

Pregnancy rate per couple (all cycles) · couples with male subfertility

It is very uncertain whether IUI in stimulated cycles changes pregnancy rate per couple (all cycles) compared with TI (very low certainty).

2 findings from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 3.14 [0.12, 81.35]
Studies not reported
Very low
Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 1.51 [0.74, 3.07]
Studies not reported
Very low

IUI in a stimulated cycle vs TI

Live birth rate per couple · couples with male subfertility

IUI in stimulated cycles showed no clear difference in live birth rate per couple (all cycles) compared with TI (low certainty).

2 findings from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 0.89 [0.3, 2.59]
Studies not reported
Low
Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 3.14 [0.12, 81.35]
Studies not reported
Very low

IUI in a stimulated cycle vs IUI

OHSS · couples with male subfertility

The review found no eligible studies for this question.

1 finding from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

IUI in a stimulated cycle vs IUI

Miscarriage · couples with male subfertility

It is very uncertain whether IUI in stimulated cycles changes miscarriage rate per couple compared with IUI (very low certainty).

1 finding from 1 review

Assisted reproductive technologies for male subfertility 2016 · Cochrane Headline outcomes only
OR 1.06 [0.2, 5.63]
Studies not reported
Very low