Findings

What do systematic reviews say?

24 questions · 31 findings · 2 reviews

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No studies found 4 · 12.9%GRADE not reported 0 · 0%Very low 8 · 25.8%Low 16 · 51.6%Moderate 3 · 9.7%High 0 · 0%

IUI in a stimulated cycle vs TI or expectant management

Live birth rate per couple · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in live birth rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (low certainty).

2 findings from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 0.82 [0.45, 1.49]
1 study · 253 participants
Low
Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.59 [0.88, 2.88]
2 studies · 208 participants
Low

IUI in a stimulated cycle vs TI or expectant management

Multiple pregnancy rate · participants with unexplained subfertility

IUI in a stimulated cycle showed no clear difference in multiple pregnancy rate per couple compared with TI or expectant management (low certainty).

2 findings from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 3.01 [0.47, 19.28]
2 studies · 454 participants
Low
Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.46 [0.55, 3.87]
4 studies · 316 participants
Low

IUI in a stimulated cycle vs TI or expectant management

Pregnancy rate · participants with unexplained subfertility

IUI in a stimulated cycle probably leads to higher pregnancy rate per couple (all cycles)‐ clomiphene citrate or… compared with TI or expectant management (moderate certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 4.68 [2.22, 9.86]
1 study · 201 participants
Moderate

IUI in a stimulated cycle vs TI or expectant management

Pregnancy rate per couple (all cycles) · participants with unexplained subfertility

IUI in a stimulated cycle may leads to higher pregnancy rate per couple (all cycles) compared with TI or expectant management (low certainty).

1 finding from 1 review

Intra‐uterine insemination for unexplained subfertility 2020 · Cochrane Headline outcomes only
OR 1.69 [1.14, 2.53]
6 studies · 517 participants
Low