Findings

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Evidence found and GRADE certainty

15 questions · 15 findings · 1 reviews

No studies found 1 · 6.7%GRADE not reported 0 · 0%Very low 10 · 66.7%Low 4 · 26.7%Moderate 0 · 0%High 0 · 0%

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Patient or population: HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)Settings: Thailand and CambodiaIntervention: IMMEDIATE initiation of cARTComparison: DEFERRED initiation of cART · HIV‐positive, treatment‐naive children aged one to 12 years old

The review found no eligible studies for this question.

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes CDC Category C disease (number of children) compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged one to 12 years old

It is very uncertain whether IMMEDIATE initiation of cART changes CDC Category B disease (numbers of children) Peto Odds Ratio compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged one to 12 years old

IMMEDIATE initiation of cART showed no clear difference in proportion of children on ART with HIV‐RNA < 50 copies/ml (Copy) compared with DEFERRED initiation of cART (low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category C disease (number of children) · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category C disease (number of children) compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

CDC Category B disease (numbers of children) Peto Odds Ratio · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes CDC Category B disease (numbers of children) Peto Odds Ratio compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Proportion of children on ART with HIV‐RNA < 50 copies/ml · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes proportion of children on ART with HIV‐RNA < 50 copies/ml compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review

IMMEDIATE initiation of cART vs DEFERRED initiation of cART

Death · HIV‐positive, treatment‐naive children aged 24 to 59 months (2 to 5 years old)

It is very uncertain whether subgroup analysis: IMMEDIATE initiation of cART changes death compared with DEFERRED initiation of cART (very low certainty).

1 finding from 1 review