Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

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1,793 questions · 1,866 findings · 339 reviews

No studies found 245 · 13.1%GRADE not reported 142 · 7.6%Very low 612 · 32.8%Low 513 · 27.5%Moderate 305 · 16.3%High 49 · 2.6%

RISPERIDONE vs CLOZAPINE ‐ all data short term

Adherence to antipsychotic medication: discontinued medication · people with both severe mental illness and substance misuse

It is very uncertain whether RISPERIDONE changes adherence to antipsychotic medication: discontinued medication compared with CLOZAPINE ‐ all data short term (very low certainty).

1 finding from 1 review

RISPERIDONE vs CLOZAPINE ‐ all data short term

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · people with both severe mental illness and substance misuse

It is very uncertain whether RISPERIDONE changes adverse effects. 1. Movement disorders ‐ any extrapyramidal compared with CLOZAPINE ‐ all data short term (very low certainty).

1 finding from 1 review

RISPERIDONE vs CLOZAPINE ‐ all data short term

Leaving the study early · people with both severe mental illness and substance misuse

It is very uncertain whether RISPERIDONE changes leaving the study early ‒ any reason compared with CLOZAPINE ‐ all data short term (very low certainty).

1 finding from 1 review

Scheduled PDE5I vs scheduled intraurethral prostaglandin E1

Erectile function · post‐prostatectomy erectile dysfunction (short‐term)

It is very uncertain whether scheduled PDE5I changes erectile function compared with scheduled intraurethral prostaglandin E1 (very low certainty).

2 findings from 1 review