What do systematic reviews say?

ICS + LAMA add‐on vs ICS dose increase

ICS + LAMA add‐on showed no clear difference in SAEs (all cause) compared with ICS dose increase (low certainty).

• Long‐acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus higher dose ICS for adults… 2015 · Cochrane Headline outcomes only
  OR 1 [0.2, 5.09]
  1 study · 174 participants
  Low