Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 1 · 14.3%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 14.3%High 5 · 71.4%

Hypofractionated radiation therapy vs conventionally fractionated radiation therapy

Local recurrence‐free survival · women treated with breast conserving therapy for early breast cancer

Hypofractionated radiation therapy showed no clear difference in local recurrence‐free survival (LR‐FS) at 10 years compared with conventionally fractionated radiation therapy (high certainty).

1 finding from 1 review

Hypofractionated radiation therapy for early breast cancer 2016 · Cochrane Headline outcomes only
HR 0.94 [0.77, 1.15]
4 studies · 7095 participants
High

Hypofractionated radiation therapy vs conventionally fractionated radiation therapy

Cosmesis · women treated with breast conserving therapy for early breast cancer

Hypofractionated radiation therapy showed no clear difference in cosmesis compared with conventionally fractionated radiation therapy (high certainty).

1 finding from 1 review

Hypofractionated radiation therapy for early breast cancer 2016 · Cochrane Headline outcomes only
RR 0.9 [0.81, 1.01]
4 studies · 2103 participants
High

Hypofractionated radiation therapy vs conventionally fractionated radiation therapy

Mortality at 10 years · women treated with breast conserving therapy for early breast cancer

Hypofractionated radiation therapy showed no clear difference in mortality at 10 years compared with conventionally fractionated radiation therapy (high certainty).

1 finding from 1 review

Hypofractionated radiation therapy for early breast cancer 2016 · Cochrane Headline outcomes only
HR 0.91 [0.8, 1.03]
3 studies · 5685 participants
High

Hypofractionated radiation therapy vs conventionally fractionated radiation therapy

Late subcutaneous toxicity · women treated with breast conserving therapy for early breast cancer

Hypofractionated radiation therapy showed no clear difference in late subcutaneous toxicity compared with conventionally fractionated radiation therapy (high certainty).

1 finding from 1 review

Hypofractionated radiation therapy for early breast cancer 2016 · Cochrane Headline outcomes only
RR 0.93 [0.83, 1.05]
4 studies · 5130 participants
High

Hypofractionated radiation therapy vs conventionally fractionated radiation therapy

Breast cancer‐specific survival · women treated with breast conserving therapy for early breast cancer

Hypofractionated radiation therapy showed no clear difference in breast cancer‐specific survival (BC‐SS) at 10 years compared with conventionally fractionated radiation therapy (high certainty).

1 finding from 1 review

Hypofractionated radiation therapy for early breast cancer 2016 · Cochrane Headline outcomes only
HR 0.91 [0.78, 1.06]
3 studies · 5685 participants
High

Hypofractionated radiation therapy vs conventionally fractionated radiation therapy

Proportion of participants with relapse‐free survival at ≥ 12 months · women treated with breast conserving therapy for early breast cancer

Hypofractionated radiation therapy showed no clear difference in relapse‐free survival (RFS) at 10 years compared with conventionally fractionated radiation therapy (moderate certainty).

1 finding from 1 review

Hypofractionated radiation therapy for early breast cancer 2016 · Cochrane Headline outcomes only
HR 0.93 [0.82, 1.05]
3 studies · 5685 participants
Moderate

Hypofractionated radiation therapy vs conventionally fractionated radiation therapy

Mastectomy rate ‐ not measured · women treated with breast conserving therapy for early breast cancer

The review found no eligible studies for this question.

1 finding from 1 review

Hypofractionated radiation therapy for early breast cancer 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found