Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

26 questions · 26 findings · 3 reviews · Headline outcomes only

No studies found 6 · 23.1%GRADE not reported 0 · 0%Very low 1 · 3.8%Low 4 · 15.4%Moderate 5 · 19.2%High 10 · 38.5%

Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy

Failure of local tumour control ‐ not reported · People undergoing radiation therapy for head and neck cancer

Hyperbaric oxygen probably leads to lower failure of local tumour control (local control) compared with air breathing to enhance the effectiveness of radiotherapy (moderate certainty).

1 finding from 1 review

Hyperbaric oxygen vs Normobaric Oxygen (NBO)

Presence of symptoms or signs at time of primary analysis (4‐6 weeks) · patients with carbon monoxide poisoning

It is very uncertain whether hyperbaric Oxygen (HBO) changes presence of symptoms or signs at time of primary analysis (4‐6 weeks) compared with normobaric Oxygen (NBO) (very low certainty).

1 finding from 1 review

Hyperbaric oxygen vs control without HBOT

Death at 1 year · any person with radiation tissue injury arising later than 6 months after irradiation (LRTI), including dysfunction or necrosis of any…

Hyperbaric oxygen therapy (HBOT) showed no clear difference in death at 1 year compared with control without HBOT (low certainty).

1 finding from 1 review