Findings

What do systematic reviews say?

6 questions · 6 findings · 4 reviews

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No studies found 1 · 16.7%GRADE not reported 1 · 16.7%Very low 1 · 16.7%Low 0 · 0%Moderate 1 · 16.7%High 2 · 33.3%

Hyperbaric oxygen vs air breathing

Adverse effects · People undergoing radiotherapy for uterine cervical cancer

Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
RR 2.05 [1.22, 3.46]
3 studies · 456 participants
High

Hyperbaric oxygen vs air breathing

Adverse effects · People with any one of a mixed group of cancers

Hyperbaric oxygen leads to higher adverse effects compared with air breathing (high certainty).

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
RR 2.35 [1.66, 3.33]
7 studies · 779 participants
High

Hyperbaric oxygen vs air breathing to enhance the effectiveness of radiotherapy

Adverse effects · People undergoing radiation therapy for head and neck cancer

Hyperbaric oxygen probably leads to higher adverse effects compared with air breathing to enhance the effectiveness of radiotherapy (moderate certainty).

1 finding from 1 review

Hyperbaric oxygenation for tumour sensitisation to radiotherapy 2018 · Cochrane Headline outcomes only
RR 2.64 [1.65, 4.23]
4 studies · 323 participants
Moderate

Hyperbaric oxygen (following replantation) vs control

Adverse effects · People with avulsed and replanted permanent (front) teeth

1 finding from 1 review

Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted 2019 · Cochrane All outcomes
Chen 2000 did not report this outcome; following email correspondence, authors reported no adverse effects were seen (uncertain whether formally assessed).
1 study
GRADE not reported

Hyperbaric oxygen therapy (HBO) following extractions vs penicillin G

Adverse effects · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

1 finding from 1 review

Interventions for preventing osteoradionecrosis of the jaws in adults receiving head and neck radiotherapy 2019 · Cochrane All outcomes
6 months
Adverse effects were an outcome of interest in the study conducting this comparison, however no mention was made of the presence or absence of any adverse events
1 study · 74 participants
Very low

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Adverse effects · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found