Findings

What do systematic reviews say?

207 questions · 210 findings · 30 reviews

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No studies found 62 · 29.5%GRADE not reported 17 · 8.1%Very low 62 · 29.5%Low 42 · 20%Moderate 26 · 12.4%High 1 · 0.5%

Individualised homeopathic medicine (two doses over 24 hours) vs placebo

Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 days
No participant needed to discontinue treatment due to adverse events.
1 study · 100 participants
GRADE not reported

Individualised homeopathic medicine (two doses over 24 hours) vs placebo

Pain free by end of study (day 6) · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…

Individualised homeopathic medicine (two doses over 24 hours) led to higher pain free by end of study (day 6) compared with placebo; GRADE not reported.

1 finding from 1 review

Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes
6 days
RR 2.00 [1.39, 2.89]
1 study · 100 participants
GRADE not reported

Tooth bleaching (carbamide or hydrogen peroxide; home and/or in-office) vs No bleaching (untreated or pH-cycling control)

Caries susceptibility, enamel demineralisation, erosion, or microhardness · Permanent teeth / enamel specimens (in vitro)

Low-quality in vitro evidence suggests that bleaching of permanent teeth does not increase susceptibility to caries, demineralisation or erosion (ungraded); the clinical question could not be answered because only in vitro studies were available.

1 finding from 1 review

Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. 2020 All outcomes
In vitro laboratory studies
Four studies at high risk of bias and one study at moderate risk reached the overall conclusion that neither home- nor in-office bleaching of permanent teeth was associated with an increased susceptibility to…
5 studies
GRADE not reported

Tooth bleaching (carbamide or hydrogen peroxide; home and/or in-office) vs No bleaching (untreated control)

Colour change / camouflage of white spot lesions (reduction of colour disparity between carious and sound enamel) · Permanent teeth with post-orthodontic white spot lesions (orthodontic patients and in vitro enamel specimens)

Bleaching may diminish colour disparities and camouflage post-orthodontic white spot lesions, but the certainty of the evidence is very low; the findings could neither support nor refute bleaching.

1 finding from 1 review

Is Bleaching Effective in Managing Post-orthodontic White-spot Lesions? A Systematic Review. 2020 All outcomes
Orthodontic patients (Knösel 2007 RCT, Germany) and in vitro laboratory studies
The results showed that bleaching of WSL can diminish colour disparities between carious and non-affected areas, but the certainty of the evidence was very low.
3 studies
GRADE not reported

12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel, professionally applied every 3 months plus home use vs Placebo gel

Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

It is very uncertain whether 12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel,… changes number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo gel (very low certainty).

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond; mean follow-up 16.6 months
RR 0.99 [0.76, 1.27]
1 study · 312 participants
Very low

Breastfeeding promotion and support (e.g. individually tailored home-based peer counselling on the importance of breastfeeding, with advice and support for healthy breastfeeding) vs usual care

Caries presence in primary teeth · For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age

Breastfeeding promotion and support (e.g. individually tailored… showed no clear difference in caries presence in primary teeth compared with standard care (low certainty).

1 finding from 1 review

Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
Children assessed at 5-6 yrs
RR 0.96 [0.89, 1.03]
2 studies · 1148 participants
Low

Breastfeeding promotion and support (e.g. individually tailored home-based peer counselling on the importance of breastfeeding, with advice and support for healthy breastfeeding) vs usual care

Dental caries · For interventions, pregnant and lactating women; for outcomes, children up to 6 years of age

The review found no eligible studies for this question.

2 findings from 1 review

Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
dmfs was listed in the SoF table but not assessed (not reported for this comparison).
0 studies
No studies found
Interventions with pregnant women, new mothers and other primary caregivers for preventing early childhood caries 2024 · Cochrane All outcomes
Children assessed at 5-6 yrs
MD -0.12 [-0.59, 0.36]
2 studies · 652 participants
Low