Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

35 questions · 51 findings · 4 reviews

No studies found 0 · 0%GRADE not reported 18 · 35.3%Very low 13 · 25.5%Low 12 · 23.5%Moderate 2 · 3.9%High 6 · 11.8%

Highest vs lowest selenium exposure

Colorectal cancer risk (16 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes colorectal cancer risk No. of participants: 712,746 (6 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Lung cancer risk (17 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes lung cancer risk No. of participants: 371,067 (11 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Breast cancer risk (14 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes breast cancer risk (women) No. of participants: 169,028 (8… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Bladder cancer risk No. of participants: 279,100 (5 observational studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes bladder cancer risk No. of participants: 279,100 (5 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Prostate cancer risk (13 studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes prostate cancer risk No. of participants: 576,667 (21 observational… compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Cancer mortality risk No. of participants: 17,448 (1 RCT) · Participants in trials with low risk of bias

Highest showed no clear difference in cancer mortality risk No. of participants: 17,448 (1 RCT) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Colorectal cancer risk (16 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in colorectal cancer risk No. of participants: 19,009 (2 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Non‐melanoma skin cancer risk No. of participants: 2027 (2 RCTs) · Participants in trials with low risk of bias

Highest showed no clear difference in non‐melanoma skin cancer risk No. of participants: 2027 (2 RCTs) compared with lowest selenium exposure (moderate certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Lung cancer risk (17 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in lung cancer risk No. of participants: 19,009 (2 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Breast cancer risk (14 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in breast cancer risk No. of participants: 802 (1 RCT) compared with lowest selenium exposure (moderate certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Bladder cancer risk No. of participants: 19,009 (2 RCTs) · Participants in trials with low risk of bias

Highest showed no clear difference in bladder cancer risk No. of participants: 19,009 (2 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Prostate cancer risk (13 studies) · Participants in trials with low risk of bias

Highest showed no clear difference in prostate cancer risk No. of participants: 18,942 (4 RCTs) compared with lowest selenium exposure (high certainty).

1 finding from 1 review

Highest vs lowest selenium exposure

Any cancer risk No. of participants: 76,239 (7 observational studies) · Participants in non experimental cohort studies on selenium and cancer

It is very uncertain whether highest changes any cancer risk No. of participants: 76,239 (7 observational studies) compared with lowest selenium exposure (very low certainty).

1 finding from 1 review

Highest BMI category (overweight/obese) vs Lowest BMI category (normal weight/underweight)

Early childhood caries (ECC) · Children (approx. 4-18 years)

In the Region: Asian countries subgroup, the BMI (highest vs lowest)-childhood caries association was significant (OR 1.70, 95% CI 1.25 to 2.32; ungraded).

17 findings from 1 review
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