Leaving the study early: insufficient response ‐ When compared with standard‐lower dose (greater than or equal to 4‐<6 mg/day) · patients with schizophrenia
STANDARD‐HIGHER DOSE (greater than or equal to 6‐<10 mg/day) showed no clear difference in leaving the study early: insufficient response ‐ When compared with… compared with ANY DOSE ‐ short term (moderate certainty).
1 finding from 1 review
Global state: 1. No clinically important improvement ‐ CGI‐I ‐ when compared with standard‐lower dose (greater than or equal to 4‐<6 mg/day) · patients with schizophrenia
STANDARD‐HIGHER DOSE (greater than or equal to 6‐<10 mg/day) showed no clear difference in global state: 1. No clinically important improvement ‐ CGI‐I ‐ when… compared with ANY DOSE ‐ short term (moderate certainty).
1 finding from 1 review
Mental state: No clinically important improvement · patients with schizophrenia
STANDARD‐HIGHER DOSE (greater than or equal to 6‐<10 mg/day) showed no clear difference in mental state: 1. No clinically important improvement ‐ PANSS ‐ when… compared with ANY DOSE ‐ short term (moderate certainty).
1 finding from 1 review
Adverse effects: 5a. Movement disorders ‐ specific symptoms ‐ EPS: unspecified ‐ versus standard‐lower dose (greater than or equal to 4‐<6 mg/day) · patients with schizophrenia
STANDARD‐HIGHER DOSE (greater than or equal to 6‐<10 mg/day) showed no clear difference in adverse effects: EPS: unspecified ‐ Versus standard‐lower dose… compared with ANY DOSE ‐ short term (moderate certainty).
1 finding from 1 review
All‐cause mortality: range 1 mo to 1 y · adults admitted to the ICU
It is very uncertain whether higher changes all‐cause mortality: range 1 mo to 1 y compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · adults admitted to the ICU
It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Quality of life (any measure): range 180 d to 1 y · adults admitted to the ICU
1 finding from 1 review
Lung injury diagnosed after randomisation (composite outcome): range 4 d to 23 d · adults admitted to the ICU
It is very uncertain whether higher changes lung injury diagnosed after randomisation (composite outcome): range… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Myocardial infarction · adults admitted to the ICU
It is very uncertain whether higher changes myocardial infarction diagnosed after randomisation: range ≤ 90 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Stroke · adults admitted to the ICU
It is very uncertain whether higher changes stroke diagnosed after randomisation: range 1 mo to 3 mo compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Sepsis diagnosed after randomisation: range 28 d to 60 d · adults admitted to the ICU
It is very uncertain whether higher changes sepsis diagnosed after randomisation: range 28 d to 60 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Mortality before hospital discharge · preterm infants
Higher showed no clear difference in mortality to hospital discharge compared with lower amino acid intake (low certainty).
1 finding from 1 review
Neurodevelopmental disability · preterm infants
It is very uncertain whether higher changes neurodevelopmental disability compared with lower amino acid intake (very low certainty).
1 finding from 1 review
Postnatal growth failure (weight < 10th percentile) · preterm infants
It is very uncertain whether higher changes postnatal growth failure at discharge (weight < 10th centile) compared with lower amino acid intake (very low certainty).
1 finding from 1 review
Weight gain · preterm infants
1 finding from 1 review
Head circumference gain (mm/week) · preterm infants
1 finding from 1 review
Retinopathy of prematurity · preterm infants
It is very uncertain whether higher changes retinopathy of prematurity compared with lower amino acid intake (very low certainty).
1 finding from 1 review
Abnormal blood urea nitrogen (various criteria) · preterm infants
Higher leads to higher abnormal blood urea nitrogen (various criteria) compared with lower amino acid intake (high certainty).
1 finding from 1 review
Live birth rate per woman · women undergoing assisted reproduction
It is very uncertain whether higher changes live birth per woman randomised: sensitivity analysis (including all… compared with lower degree of injury (very low certainty).
1 finding from 1 review
Miscarriage · women undergoing assisted reproduction
It is very uncertain whether higher changes miscarriage per woman randomised: sensitivity analysis (including… compared with lower degree of injury (very low certainty).
1 finding from 1 review