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Evidence found and GRADE certainty

269 questions · 313 findings · 39 reviews

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No studies found 22 · 7%GRADE not reported 124 · 39.6%Very low 73 · 23.3%Low 62 · 19.8%Moderate 27 · 8.6%High 5 · 1.6%

Higher maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration

Pre‐eclampsia · pregnant women and their infants..

Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Pre-eclampsia: OR 0.56 (95% CI 0.39 to 0.80), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.

1 finding from 1 review

Higher maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration

Head circumference (mm) · pregnant women and their infants..

Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Head circumference: WMD 0.05 (95% CI -0.24 to 0.34), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Higher maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration

Birth length · pregnant women and their infants..

Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Birth length: WMD 0.19 (95% CI -0.26 to 0.65), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.

1 finding from 1 review

Higher maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration

Birthweight (g) · pregnant women and their infants..

Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Birth weight: WMD 130.9 (95% CI 75.1 to 186.7), statistically significant. Umbrella review outcome-level evidence grade: Probable.

1 finding from 1 review

Higher maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration

Gestational diabetes · pregnant women and their infants..

Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Gestational diabetes: OR 0.67 (95% CI 0.53 to 0.85), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Higher drinking-water fluoride exposure vs Lower water fluoride concentration (concurrent control)

Dental fluorosis of aesthetic concern (Dean's Index, TFI, TSIF) · Populations of all ages (mostly children) exposed to drinking water with differing fluoride concentrations

Higher water fluoride concentration (fluoridated water; natural or… may leads to higher dental fluorosis of aesthetic concern (Dean's Index, TFI, TSIF) compared with lower water fluoride concentration (concurrent control) (low certainty).

1 finding from 1 review

Higher drinking-water fluoride exposure vs Lower water fluoride concentration (concurrent control)

Adverse effects: dental fluorosis · Populations of all ages (mostly children) exposed to drinking water with differing fluoride concentrations

Higher water fluoride concentration (fluoridated water; natural or… may leads to higher dental fluorosis of any level (all severities) compared with lower water fluoride concentration (concurrent control) (low certainty).

1 finding from 1 review

Granulocyte-macrophage colony-stimulating factor (GM-CSF), higher dose (1260 to 12,600 micrograms) vs Granulocyte-macrophage colony-stimulating factor (GM-CSF), lower dose (12.6 to 126 micrograms)

Oral mucositis (severe) · breast cancer patients undergoing chemotherapy

Granulocyte-macrophage colony-stimulating factor (GM-CSF), higher… led to higher oral mucositis (severe) compared with granulocyte-macrophage colony-stimulating factor (GM-CSF), lower…; GRADE not reported.

1 finding from 1 review

Higher JIA disease activity/severity (e.g., high JADAS/activity scores, polyarticular RF-negative subtype, active disease, anti-TNFalpha or cyclosporine medication) vs Lower JIA disease activity / inactive or milder JIA

Prevalence and severity of oral and TMJ diseases/conditions (periodontal status and dental caries) · Children and adolescents with juvenile idiopathic arthritis (JIA)

Some studies suggested greater JIA disease activity/severity (and certain medications) was associated with worse periodontal and caries outcomes, but small samples meant no solid conclusion could be drawn (ungraded).

1 finding from 1 review