What do systematic reviews say?

Higher vs lower FiO2 or targets of arterial oxygenation

It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

• Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the… 2023 · Cochrane Headline outcomes only
  RR 1.01 [0.96, 1.06]
  17 studies · 9466 participants
  Very low

Children: higher dose/longer course vs lower dose/shorter course

• Different oral corticosteroid regimens for acute asthma 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 201 participants
  GRADE not reported

Summary of findings table ‐ High‐dose dexamethasone (12 mg or higher) vs low‐dose dexamethasone (6 mg to 8 mg)

• Systemic corticosteroids for the treatment of COVID‐19: Equity‐related analyses and update on evidence 2022 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1080 participants
  Very low

Higher BP target (< 150‐160/95‐105 mmHg) vs lower BP target (< 140/90 mmHg)

Higher BP target (< 150‐160/95‐105 mmHg) showed no clear difference in cardiovascular serious adverse events compared with lower BP target (< 140/90 mmHg) (low certainty).

• Blood pressure targets for hypertension in older adults 2017 · Cochrane Headline outcomes only
  RR 1.19 [0.98, 1.45]
  3 studies · 8221 participants
  Low