What do systematic reviews say?

High vs non‐high (medium or low) dose regimen

High showed no clear difference in mortality compared with non‐high (medium or low) dose regimen (low certainty).

• Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding 2013 · Cochrane Headline outcomes only
  RR 0.85 [0.47, 1.54]
  12 studies · 1667 participants
  Low

High vs non‐high (medium or low) dose regimen

High showed no clear difference in rebleeding compared with non‐high (medium or low) dose regimen (low certainty).

• Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding 2013 · Cochrane Headline outcomes only
  RR 1.27 [0.96, 1.67]
  13 studies · 1716 participants
  Low

High vs non‐high (medium or low) dose regimen

High showed no clear difference in surgery compared with non‐high (medium or low) dose regimen (low certainty).

• Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding 2013 · Cochrane Headline outcomes only
  RR 1.33 [0.63, 2.77]
  9 studies · 1270 participants
  Low

High vs non‐high (medium or low) dose regimen

High showed no clear difference in further EHT compared with non‐high (medium or low) dose regimen (low certainty).

• Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding 2013 · Cochrane Headline outcomes only
  RR 1.39 [0.88, 2.18]
  6 studies · 902 participants
  Low

High vs non‐high (medium or low) dose regimen

• Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding 2013 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 1069 participants
  Moderate

High vs non‐high (medium or low) dose regimen

• Comparison of different regimens of proton pump inhibitors for acute peptic ulcer bleeding 2013 · Cochrane Headline outcomes only
  no estimate extracted
  6 studies · 1069 participants
  Moderate