Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

74 questions · 76 findings · 6 reviews · Heart

No studies found 5 · 6.6%GRADE not reported 0 · 0%Very low 20 · 26.3%Low 22 · 28.9%Moderate 19 · 25%High 10 · 13.2%

High vs low omega‐3 fats

Serum low‐density lipoprotein (LDL, mmol/L) · adults with or without existing CVD
2 findings from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Myocardial infarction · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in myocardial infarction compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Stroke · people with or without existing cardiovascular disease, men and women

It is very uncertain whether homocysteine‐lowering interventions (high dose) changes stroke compared with homocysteine‐lowering interventions (low dose) (very low certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review