Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 40%Moderate 3 · 60%High 0 · 0%

High vs low or no hyaluronic acid

Live birth rate · couples undergoing embryo transfer

High probably leads to higher live birth rate ‐ high vs low or no hyaluronic acid compared with low or no hyaluronic acid (moderate certainty).

1 finding from 1 review

Hyaluronic acid in embryo transfer media for assisted reproductive technologies 2020 · Cochrane Headline outcomes only
RR 1.21 [1.11, 1.31]
10 studies · 4066 participants
Moderate

High vs low or no hyaluronic acid

Clinical pregnancy rate · couples undergoing embryo transfer

High probably leads to higher clinical pregnancy rate ‐ high vs low or no hyaluronic acid compared with low or no hyaluronic acid (moderate certainty).

1 finding from 1 review

Hyaluronic acid in embryo transfer media for assisted reproductive technologies 2020 · Cochrane Headline outcomes only
RR 1.16 [1.09, 1.23]
17 studies · 5247 participants
Moderate

High vs low or no hyaluronic acid

Miscarriage · couples undergoing embryo transfer

High showed no clear difference in miscarriage rate compared with low or no hyaluronic acid (low certainty).

1 finding from 1 review

Hyaluronic acid in embryo transfer media for assisted reproductive technologies 2020 · Cochrane Headline outcomes only
RR 0.82 [0.67, 1]
7 studies · 3091 participants
Low

High vs low or no hyaluronic acid

Multiple pregnancy rate · couples undergoing embryo transfer

High probably leads to higher multiple pregnancy rate compared with low or no hyaluronic acid (moderate certainty).

1 finding from 1 review

Hyaluronic acid in embryo transfer media for assisted reproductive technologies 2020 · Cochrane Headline outcomes only
RR 1.45 [1.24, 1.7]
7 studies · 3337 participants
Moderate

High vs low or no hyaluronic acid

Adverse event rate · couples undergoing embryo transfer

High showed no clear difference in adverse event rate compared with low or no hyaluronic acid (low certainty).

1 finding from 1 review

Hyaluronic acid in embryo transfer media for assisted reproductive technologies 2020 · Cochrane Headline outcomes only
RR 0.86 [0.4, 1.84]
3 studies · 1487 participants
Low