Findings

What do systematic reviews say?

26 questions · 26 findings · 4 reviews · Vascular

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No studies found 6 · 23.1%GRADE not reported 4 · 15.4%Very low 11 · 42.3%Low 5 · 19.2%Moderate 0 · 0%High 0 · 0%

High‐dose vs low‐dose regimens of thrombolytic agents

30‐Day mortality · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

Vessel patency (at end of treatment) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

Duration of thrombolysis (to end of treatment) · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

Stroke · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

Major bleeding · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

30‐Day amputation‐free survival · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High‐dose vs low‐dose regimens of thrombolytic agents

Amputation · patients with < 42 days' limb ischaemiaa

1 finding from 1 review

Infusion techniques for peripheral arterial thrombolysis 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 302 participants
Very low

High cell dose vs low cell dose

All‐cause mortality during hospital stay · people with critical limb ischaemia

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
GRADE not reported

High cell dose vs low cell dose

Rate of amputation · people with critical limb ischaemia

It is very uncertain whether high cell dose changes amputation rate Assessed during in‐patient stay (Losordo 2012) compared with low cell dose (very low certainty).

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
RR 3.21 [0.87, 11.9]
1 study · 16 participants
Very low

High cell dose vs low cell dose

Ulcer healing · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High cell dose vs low cell dose

Rest‐pain relief · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High cell dose vs low cell dose

Improvement in lower limb perfusion: ABI · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High cell dose vs low cell dose

Improvement in lower limb perfusion: TcO₂ reading in mmHg · people with critical limb ischaemia

The review found no eligible studies for this question.

1 finding from 1 review

Autologous cells derived from different sources and administered using different regimens for 'no‐option' critical… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Higher‐dose heparin vs standard‐dose heparin

Total VTE · people undergoing bariatric surgery

Higher‐dose heparin showed no clear difference in VTE compared with standard‐dose heparin (low certainty).

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
RR 0.55 [0.05, 5.99]
4 studies · 597 participants
Low

Higher‐dose heparin vs standard‐dose heparin

Major bleeding · people undergoing bariatric surgery

Higher‐dose heparin showed no clear difference in major bleeding compared with standard‐dose heparin (low certainty).

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
RR 1.19 [0.48, 2.96]
4 studies · 597 participants
Low

Higher‐dose heparin vs standard‐dose heparin

All‐cause mortality · people undergoing bariatric surgery

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 597 participants
Low

Higher‐dose heparin vs standard‐dose heparin

VTE‐related mortality4 · people undergoing bariatric surgery

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 597 participants
Low

Higher‐dose heparin vs standard‐dose heparin

PE · people undergoing bariatric surgery

It is very uncertain whether higher‐dose heparin changes PE compared with standard‐dose heparin (very low certainty).

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
RR 0.37 [0.02, 8.92]
2 studies · 310 participants
Very low

Higher‐dose heparin vs standard‐dose heparin

Deep vein thrombosis · people undergoing bariatric surgery

It is very uncertain whether higher‐dose heparin changes DVT compared with standard‐dose heparin (very low certainty).

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
RR 1.1 [0.07, 17.4]
4 studies · 597 participants
Very low

Higher‐dose heparin vs standard‐dose heparin

Thrombocytopenia · people undergoing bariatric surgery

It is very uncertain whether higher‐dose heparin changes adverse events (thrombocytopenia) compared with standard‐dose heparin (very low certainty).

1 finding from 1 review

Pharmacological interventions for preventing venous thromboembolism in people undergoing bariatric surgery 2022 · Cochrane Headline outcomes only
RR 1.1 [0.07, 17.4]
2 studies · 310 participants
Very low