All‐cause mortality: range 1 mo to 1 y · adults admitted to the ICU
It is very uncertain whether higher changes all‐cause mortality: range 1 mo to 1 y compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · adults admitted to the ICU
It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Quality of life (any measure): range 180 d to 1 y · adults admitted to the ICU
1 finding from 1 review
Lung injury diagnosed after randomisation (composite outcome): range 4 d to 23 d · adults admitted to the ICU
It is very uncertain whether higher changes lung injury diagnosed after randomisation (composite outcome): range… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Myocardial infarction · adults admitted to the ICU
It is very uncertain whether higher changes myocardial infarction diagnosed after randomisation: range ≤ 90 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Stroke · adults admitted to the ICU
It is very uncertain whether higher changes stroke diagnosed after randomisation: range 1 mo to 3 mo compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Sepsis diagnosed after randomisation: range 28 d to 60 d · adults admitted to the ICU
It is very uncertain whether higher changes sepsis diagnosed after randomisation: range 28 d to 60 d compared with lower FiO2 or targets of arterial oxygenation (very low certainty).
1 finding from 1 review
Mortality before hospital discharge · patients with ALI and ARDS
High levels of PEEP showed no clear difference in mortality before hospital discharge compared with low levels of PEEP (moderate certainty).
1 finding from 1 review
Oxygen efficiency (PaO2/FiO2) day 1 postoperative · patients with ALI and ARDS
1 finding from 1 review
Oxygen efficiency (PaO2/FiO2) day 3 postoperative · patients with ALI and ARDS
1 finding from 1 review
Oxygen efficiency (PaO2/FIO2). Day 7 · patients with ALI and ARDS
1 finding from 1 review
Barotrauma · patients with ALI and ARDS
High levels of PEEP showed no clear difference in barotrauma compared with low levels of PEEP (low certainty).
1 finding from 1 review
Ventilator‐free days up to day 28 · patients with ALI and ARDS
1 finding from 1 review
Outcomes** · people with Acute Respiratory Distress Syndrome
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Mortality (at 30 days or until hospital discharge) · people with Acute Respiratory Distress Syndrome
It is very uncertain whether high‐frequency oscillation changes mortality (at 30 days or until hospital discharge) compared with conventional ventilation (very low certainty).
1 finding from 1 review
Mortality (at 6 months) · people with Acute Respiratory Distress Syndrome
It is very uncertain whether high‐frequency oscillation changes mortality (at 6 months) compared with conventional ventilation (very low certainty).
1 finding from 1 review
Treatment failure · people with Acute Respiratory Distress Syndrome
It is very uncertain whether high‐frequency oscillation changes treatment failure compared with conventional ventilation (very low certainty).
1 finding from 1 review
Duration of mechanical ventilation · people with Acute Respiratory Distress Syndrome
1 finding from 1 review
Barotrauma · people with Acute Respiratory Distress Syndrome
It is very uncertain whether high‐frequency oscillation changes barotrauma compared with conventional ventilation (very low certainty).
1 finding from 1 review
Hypotension · people with Acute Respiratory Distress Syndrome
It is very uncertain whether high‐frequency oscillation changes hypotension compared with conventional ventilation (very low certainty).
1 finding from 1 review