Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

637 questions · 714 findings · 96 reviews

No studies found 98 · 13.7%GRADE not reported 191 · 26.8%Very low 157 · 22%Low 161 · 22.5%Moderate 87 · 12.2%High 20 · 2.8%

High vs low dose pegylated interferon alpha‐2a or alpha‐2b

PEG interferon (combined) · patients on HD with HCV infection

High showed no clear difference in PEG interferon (combined) compared with low dose pegylated interferon alpha‐2a or alpha‐2b (moderate certainty).

3 findings from 1 review

High vs low stimulation

50% or greater reduction in seizure frequency · people with focal seizures

High probably leads to higher 50% reduction in seizure frequency (responders) compared with low stimulation (moderate certainty).

1 finding from 1 review

High vs low stimulation

Voice Alteration or Hoarseness · people with focal seizures

High probably leads to higher voice alteration or hoarseness compared with low stimulation (moderate certainty).

1 finding from 1 review

High vs low stimulation

Paraesthesia · people with focal seizures

High showed no clear difference in paraesthesias compared with low stimulation (moderate certainty).

1 finding from 1 review