Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

637 questions · 714 findings · 96 reviews

No studies found 98 · 13.7%GRADE not reported 191 · 26.8%Very low 157 · 22%Low 161 · 22.5%Moderate 87 · 12.2%High 20 · 2.8%

Higher vs lower omega‐6: additional key outcomes

All‐cause mortality Study duration range 12‐96 months Omega‐6 dose range 1.5%‐24.5% E · adults with or without existing CVD

Higher showed no clear difference in all‐cause mortality Study duration range 12‐96 months Omega‐6 dose… compared with lower omega‐6: primary outcomes (low certainty).

1 finding from 1 review

Higher vs lower omega‐6: additional key outcomes

Cardiovascular mortality · adults with or without existing CVD

It is very uncertain whether higher changes cardiovascular mortality Study duration range 24‐96 months Omega‐6… compared with lower omega‐6: primary outcomes (very low certainty).

1 finding from 1 review

Higher vs lower omega‐6: additional key outcomes

MACCEs Study duration range 24‐96 months Omega‐6 dose range 2.8%‐12.0% E · adults with or without existing CVD

It is very uncertain whether higher changes MACCEs Study duration range 24‐96 months Omega‐6 dose range… compared with lower omega‐6: primary outcomes (very low certainty).

1 finding from 1 review

Higher vs lower omega‐6: additional key outcomes

Fatal or nonfatal stroke · adults with or without existing CVD

It is very uncertain whether higher changes stroke: fatal or non‐fatal Study duration range 24‐96 months Omega‐6… compared with lower omega‐6: primary outcomes (very low certainty).

1 finding from 1 review

Higher vs lower omega‐6: additional key outcomes

MI Study duration range 12‐96 months Omega‐6 dose range 2.8%‐24.5% E · adults with or without existing CVD

Higher showed no clear difference in MI Study duration range 12‐96 months Omega‐6 dose range 2.8%‐24.5% E compared with lower omega‐6: additional key outcomes (low certainty).

1 finding from 1 review