What do systematic reviews say?

High vs low blood pressure target

It is very uncertain whether high changes quality of life compared with low blood pressure target (very low certainty).

• High versus low blood pressure targets for cardiac surgery while on cardiopulmonary bypass 2022 · Cochrane Headline outcomes only
  RR 0.78 [0.3, 2.01]
  1 study · 218 participants
  Very low

Higher vs lower FiO2 or targets of arterial oxygenation

• Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1649 participants
  Very low

High‐dose vs low‐dose rFVIIa

The review found no eligible studies for this question.

• Bypassing agent prophylaxis in people with hemophilia A or B with inhibitors 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

ASA + high‐dose LMWH vs ASA + low‐dose LMWH or UFH

The review found no eligible studies for this question.

• Antiplatelet and anticoagulant agents for primary prevention of thrombosis in individuals with antiphospholipid… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

High‐pressure garment therapy vs low‐pressure garment therapy

The review found no eligible studies for this question.

• Pressure‐garment therapy for preventing hypertrophic scarring after burn injury 2024 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

High‐treatment‐dose vitamin D (greater than 1000 IU/day) vs low‐treatment‐dose vitamin D (400 IU/day to 1000 IU/day)

• Vitamin D for the treatment of inflammatory bowel disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 46 participants
  Very low

High dose 5‐ASA vs low dose 5‐ASA

The review found no eligible studies for this question.

• Oral 5‐aminosalicylic acid for maintenance of surgically‐induced remission in Crohn's disease 2019 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

High‐dose vs low‐dose coenzyme Q10 and vitamin E

• Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

High‐dose vs low‐dose coenzyme Q10 and vitamin E

• Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Higher parental / maternal education vs Lower parental education (reference)

Higher parental education is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  Adolescents from families with higher incomes and higher levels of maternal education have better OHRQoL scores [34]. Children from families with high income, parental education and family economy had better OHRQoL [42].
  Studies not reported
  GRADE not reported

Higher family income / socioeconomic status vs Lower income / worse socioeconomic status

Higher family income / better socioeconomic status is associated with better OHRQoL in adolescents (narrative synthesis; no pooled estimate or GRADE rating).

• Oral-health-related quality of life in adolescents: umbrella review. 2023 All outcomes

  Community/school/clinic settings; adolescents 10-19 years; included reviews conducted in multiple countries
  Adolescents from families with higher incomes and higher levels of maternal education have better OHRQoL scores [34]. Worse oral health status, older age, female sex and worse socioeconomic status were significantly…
  Studies not reported
  GRADE not reported