Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 9 findings · 2 reviews

No studies found 4 · 44.4%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 11.1%Moderate 0 · 0%High 4 · 44.4%

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Overall survival at 5‐year · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in overall survival at 5‐year compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Event‐free survival · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in event‐free survival at 5‐year compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Treatment‐related mortality · women with early poor prognosis breast cancer

High‐dose chemotherapy leads to higher treatment‐related mortality compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy vs chemotherapy without bone marrow transplant or stem cell rescue

Second cancers at 4 ‐ 9‐year median · women with early poor prognosis breast cancer

High‐dose chemotherapy showed no clear difference in second cancers at 4 ‐ 9‐year median compared with chemotherapy without bone marrow transplant or stem cell rescue (high certainty).

1 finding from 1 review

High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation

Event‐free survival · children, adolescents, and young adults with primary metastatic Ewing sarcoma

High‐dose chemotherapy followed by autologous haematopoietic cell… showed no clear difference in event‐free survival (reported as number of participants with… compared with conventional chemotherapy plus whole lung irradiation (low certainty).

1 finding from 1 review

High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation

Overall survival · children, adolescents, and young adults with primary metastatic Ewing sarcoma

The review found no eligible studies for this question.

1 finding from 1 review

High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation

Quality‐adjusted survival · children, adolescents, and young adults with primary metastatic Ewing sarcoma

The review found no eligible studies for this question.

1 finding from 1 review

High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation

Toxicity · children, adolescents, and young adults with primary metastatic Ewing sarcoma

The review found no eligible studies for this question.

1 finding from 1 review

High‐dose chemotherapy followed by autologous haematopoietic cell transplantation vs conventional chemotherapy plus whole lung irradiation

Progression‐free survival · children, adolescents, and young adults with primary metastatic Ewing sarcoma

The review found no eligible studies for this question.

1 finding from 1 review