Findings

What do systematic reviews say?

6 questions · 8 findings · 4 reviews · Headline outcomes only

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No studies found 2 · 25%GRADE not reported 1 · 12.5%Very low 3 · 37.5%Low 2 · 25%Moderate 0 · 0%High 0 · 0%

High‐dose vs standard‐dose strategies

Side effects (tachycardia, agitation, or feed intolerance) leading to a reduction in dose or withholding of caffeine · preterm infants with or at risk for apnea of prematurity

It is very uncertain whether high‐dose changes side effects (tachycardia, agitation or feed intolerance) leading to… compared with standard‐dose strategies (very low certainty).

3 findings from 1 review

Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity 2023 · Cochrane Headline outcomes only
RR 1.92 [0.53, 6.9]
2 studies · 150 participants
Very low
Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found
Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity 2023 · Cochrane Headline outcomes only
RR 1.66 [0.86, 3.23]
5 studies · 593 participants
Low

High‐dose vs standard‐dose strategies

Side effects (tachycardia, agitation, or feed intolerance) leading to a reduction in dose or withholding of caffeine · preterm infants at risk for apnea

The review found no eligible studies for this question.

1 finding from 1 review

Caffeine dosing regimens in preterm infants with or at risk for apnea of prematurity 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High‐dose vs low‐dose coenzyme Q10 and vitamin E

Adverse effects (during study) · people with speech disorder resulting from hereditary ataxias

1 finding from 1 review

Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
GRADE not reported

First‐line high‐dose thiazide vs placebo

Withdrawals due to adverse events · adults with primary hypertension

1 finding from 1 review

First‐line drugs for hypertension 2018 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 15170 participants
Low

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Adverse effects: abdominal mass · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings ‐ high‐dose pancreatic enzymes vs low‐dose pancreatic enzymes

Abdominal pain · adults and children with cystic fibrosis

1 finding from 1 review

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low