Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Vascular

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

Heparin vs normal saline solution locking

Occlusion of CVC (combining participant and catheter as unit of analysis) Blood withdrawing · adults with CVCs

Heparin may leads to lower occlusion of CVC (combining participant, and catheter as unit of… compared with normal saline solution locking (low certainty).

1 finding from 1 review

Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults 2022 · Cochrane Headline outcomes only
RR 0.7 [0.51, 0.95]
10 studies · 1672 participants
Low

Heparin vs normal saline solution locking

Duration of catheter patency (days; combining participant and catheter as unit of analysis) Blood withdrawing · adults with CVCs

1 finding from 1 review

Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults 2022 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 1788 participants
Low

Heparin vs normal saline solution locking

CVC‐related bloodstream infections (positive microbiological culture, participant as unit of analysis) · adults with CVCs

It is very uncertain whether heparin changes CVC‐related bloodstream infections (positive microbiological… compared with normal saline solution locking (very low certainty).

1 finding from 1 review

Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults 2022 · Cochrane Headline outcomes only
RR 0.66 [0.08, 5.8]
3 studies · 1127 participants
Very low

Heparin vs normal saline solution locking

All‐cause mortality · adults with CVCs

It is very uncertain whether heparin changes mortality compared with normal saline solution locking (very low certainty).

1 finding from 1 review

Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults 2022 · Cochrane Headline outcomes only
RR 0.76 [0.44, 1.31]
3 studies · 1100 participants
Very low

Heparin vs normal saline solution locking

Haemorrhage · adults with CVCs

It is very uncertain whether heparin changes haemorrhage from any site compared with normal saline solution locking (very low certainty).

1 finding from 1 review

Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults 2022 · Cochrane Headline outcomes only
RR 1.54
3 studies · 1197 participants
Very low

Heparin vs normal saline solution locking

Heparin‐induced thrombocytopaenia · adults with CVCs

It is very uncertain whether heparin changes heparin‐induced thrombocytopaenia compared with normal saline solution locking (very low certainty).

1 finding from 1 review

Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults 2022 · Cochrane Headline outcomes only
RR 0.21 [0.01, 4.27]
3 studies · 443 participants
Very low