Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Schizophrenia

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No studies found 0 · 0%GRADE not reported 4 · 57.1%Very low 0 · 0%Low 0 · 0%Moderate 1 · 14.3%High 2 · 28.6%

HALOPERIDOL + PROMETHAZINE vs lorazepam

Tranquil or asleep: Not tranquil or asleep ‐ by 30 mins · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE leads to lower tranquil or asleep: Not tranquil or asleep ‐ by 30 mins compared with BENZODIAZEPINES ‐ LORAZEPAM (high certainty).

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 0.26 [0.1, 0.68]
1 study · 200 participants
High

HALOPERIDOL + PROMETHAZINE vs lorazepam

Global state: Needing restraints or seclusion ‐ by 12 hours · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in global state: Needing restraints or seclusion ‐ by 12 hours compared with BENZODIAZEPINES ‐ LORAZEPAM (moderate certainty).

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 0.82 [0.35, 1.89]
1 study · 200 participants
Moderate

HALOPERIDOL + PROMETHAZINE vs lorazepam

Adverse effects: Specific and serious adverse effect ‐ by 24 hours Central nervous system ‐ excessive sedation · people with psychosis‐induced aggression

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

HALOPERIDOL + PROMETHAZINE vs lorazepam

Adverse effect: Specific ‐ Death · people with psychosis‐induced aggression

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

HALOPERIDOL + PROMETHAZINE vs lorazepam

Service outcomes: Not discharged ‐ by 4 hours · people with psychosis‐induced aggression

HALOPERIDOL + PROMETHAZINE showed no clear difference in service outcomes: Not discharged ‐ by 4 hours compared with BENZODIAZEPINES ‐ LORAZEPAM (high certainty).

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
RR 1.13 [0.85, 1.5]
1 study · 200 participants
High

HALOPERIDOL + PROMETHAZINE vs lorazepam

Aggression · people with psychosis‐induced aggression

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

HALOPERIDOL + PROMETHAZINE vs lorazepam

Economic outcomes: Cost of care · people with psychosis‐induced aggression

1 finding from 1 review

Haloperidol plus promethazine for psychosis‐induced aggression 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported