Findings

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Evidence found and GRADE certainty

43 questions · 43 findings · 3 reviews

No studies found 7 · 16.3%GRADE not reported 5 · 11.6%Very low 17 · 39.5%Low 10 · 23.3%Moderate 2 · 4.7%High 2 · 4.7%

HALOPERIDOL vs ARIPIPRAZOLE

Adverse effects: any serious, specific ‐ dystonia during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: any serious, specific ‐ dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Adverse effects ‐ cardiovascular ‐ hypotension · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ cardiovascular ‐ hypotension compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs chlorpromazine

Adverse effects: specific ‐ seizure · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: specific ‐ central nervous system ‐ seizures compared with OTHER ANTIPSYCHOTIC: b. CHLORPROMAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: d. LOXAPINE

Global outcome: specific Not sedated at 60 minutes * · patients to psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: specific Not sedated at 60 minutes * compared with OTHER ANTIPSYCHOTIC: d. LOXAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: d. LOXAPINE

Specific behaviour ‐ Aggression ‐ no overall improvement · patients to psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes specific behaviour ‐ aggression ‐ no overall improvement compared with OTHER ANTIPSYCHOTIC: d. LOXAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: d. LOXAPINE

Adverse effects: Specific ‐ dystonia between 0‐3 days (IM phase) · patients to psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ dystonia between 0‐3 days (IM phase) compared with OTHER ANTIPSYCHOTIC: d. LOXAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: d. LOXAPINE

Adverse effects: Specific ‐ rigidity between 0‐3 days (IM phase) · patients to psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ rigidity between 0‐3 days (IM phase) compared with OTHER ANTIPSYCHOTIC: d. LOXAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OLANZAPINE

Specific behaviour ‐ threat or injury to self or others average change score (ABS, high = worse) at 2 hours · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes specific behaviour ‐ threat or injury to self or others compared with OTHER ANTIPSYCHOTIC: e. OLANZAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OLANZAPINE

Adverse effects: Specific ‐ dystonia during 24 hours · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: e. OLANZAPINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs OTHER ANTIPSYCHOTIC: f. PERPHENAZINE

Adverse effect: Specific ‐ hypotensive episode · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effect: Specific ‐ hypotensive episode compared with OTHER ANTIPSYCHOTIC: f. PERPHENAZINE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Specific behaviours ‐ agitation >50% reduction in PANSS‐EC score · patients with psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in specific behaviours ‐ agitation >50% reduction in PANSS‐EC score compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (low certainty).

1 finding from 1 review

HALOPERIDOL vs RISPERIDONE

Adverse effects: specific ‐ acute dystonia · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ acute dystonia during 24 hours compared with OTHER ANTIPSYCHOTIC: h. RISPERIDONE (very low certainty).

1 finding from 1 review