Findings

What do systematic reviews say?

6 questions · 6 findings · 3 reviews

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 3 · 50%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

HALOPERIDOL vs QUETIAPINE

Adverse effects · psychosis‐induced aggression or agitation

HALOPERIDOL may leads to higher adverse effects compared with OTHER ANTIPSYCHOTICS: g. QUETIAPINE (low certainty).

1 finding from 1 review

Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
RR 1.81 [1.19, 2.77]
1 study · 80 participants
Low

HALOPERIDOL vs first‐generation antipsychotics

Number of participants reporting an adverse event · patients with schizophrenia

Haloperidol showed no clear difference in adverse effects: number of participants with at least one adverse… compared with first‐generation antipsychotics (low certainty).

1 finding from 1 review

Haloperidol versus first‐generation antipsychotics for the treatment of schizophrenia and other psychotic disorders 2015 · Cochrane Headline outcomes only
RR 1.06 [0.94, 1.2]
10 studies · 693 participants
Low

HALOPERIDOL vs first‐generation antipsychotics

Adverse events as N of participants with at least one adverse event objective · patients with schizophrenia

It is very uncertain whether haloperidol changes adverse effects: number of participants with at least one adverse… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

Haloperidol versus first‐generation antipsychotics for the treatment of schizophrenia and other psychotic disorders 2015 · Cochrane Headline outcomes only
RR 1.07 [0.58, 1.97]
2 studies · 137 participants
Very low

HALOPERIDOL vs first‐generation antipsychotics

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether haloperidol changes adverse effects: extrapyramidal side effects: number of participants… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

Haloperidol versus first‐generation antipsychotics for the treatment of schizophrenia and other psychotic disorders 2015 · Cochrane Headline outcomes only
RR 1.12 [0.95, 1.31]
17 studies · 998 participants
Very low

HALOPERIDOL vs first‐generation antipsychotics

Adverse effects: extrapyramidal side effects: number of participants with at least one extrapyramidal side effect (medium term) · patients with schizophrenia

It is very uncertain whether haloperidol changes adverse effects: extrapyramidal side effects: number of participants… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

Haloperidol versus first‐generation antipsychotics for the treatment of schizophrenia and other psychotic disorders 2015 · Cochrane Headline outcomes only
RR 1.04 [0.62, 1.75]
1 study · 80 participants
Very low

HALOPERIDOL vs OTHER ANTIPSYCHOTICS

Adverse effects ‐ any serious, specific adverse effects · people with long‐term aggression in psychosis

The review found no eligible studies for this question.

1 finding from 1 review

Haloperidol for long‐term aggression in psychosis 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found