Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 2 · 33.3%Low 3 · 50%Moderate 0 · 0%High 0 · 0%

HALOPERIDOL vs COMBINATIONS: e. HALOPERIDOL + RISPERIDONE

Specific adverse events · psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in adverse effects: specific compared with COMBINATIONS: e. HALOPERIDOL + RISPERIDONE (low certainty).

1 finding from 1 review

Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
RR 0.88 [0.48, 1.6]
1 study · 100 participants
Low

HALOPERIDOL vs COMBINATIONS: c. HALOPERIDOL + PROMETHAZINE

Adverse effects: specific ‐ seizure · psychosis‐induced aggression or agitation

HALOPERIDOL showed no clear difference in adverse effects: specific ‐ seizure compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (low certainty).

1 finding from 1 review

Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
RR 2.05 [0.19, 22.39]
1 study · 316 participants
Low

HALOPERIDOL vs COMBINATIONS: c. HALOPERIDOL + PROMETHAZINE

Adverse effects: specific ‐ acute dystonia · psychosis‐induced aggression or agitation

HALOPERIDOL may leads to higher adverse effects: specific ‐ acute dystonia compared with COMBINATIONS: d. HALOPERIDOL + PROMETHAZINE (low certainty).

1 finding from 1 review

Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
RR 19.48 [1.14, 331.92]
1 study · 316 participants
Low

HALOPERIDOL vs COMBINATIONS: d. QUETIAPINE + MAGNESIUM VALPROATE

Adverse effect: any serious, specific ‐ not reported · patients with psychosis‐induced aggression or agitation

The review found no eligible studies for this question.

1 finding from 1 review

Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Adverse effects: specific ‐ dystonia · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ dystonia (only reported if occurred in… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
RR 8.25 [0.46, 147.45]
1 study · 67 participants
Very low

HALOPERIDOL vs COMBINATIONS: b. HALOPERIDOL + LORAZEPAM

Adverse effects: Specific ‐ hypertonia/rigidity (only reported if occurred in ≥9%) during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ hypertonia/rigidity (only reported if… compared with COMBINATIONS: b. HALOPERIDOL + LORAZEPAM (very low certainty).

1 finding from 1 review

Haloperidol for psychosis‐induced aggression or agitation (rapid tranquillisation) 2017 · Cochrane Headline outcomes only
RR 2.74 [0.3, 25.05]
1 study · 67 participants
Very low