Findings

What do systematic reviews say?

11 questions · 11 findings · 1 reviews · Gynaecology and Fertility

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 9.1%Low 9 · 81.8%Moderate 1 · 9.1%High 0 · 0%

GnRHa depot vs GnRHa daily injection

Ongoing pregnancy / live birth rate per woman · women undergoing pituitary suppression in assisted reproduction

GnRHa depot showed no clear difference in live birth/ongoing pregnancy rate per woman Delivery of one or more… compared with gnRHa daily injection (low certainty).

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
OR 0.95 [0.7, 1.31]
7 studies · 873 participants
Low

GnRHa depot vs GnRHa daily injection

Clinical pregnancy rate · women undergoing pituitary suppression in assisted reproduction

GnRHa depot showed no clear difference in clinical pregnancy rate per woman Identified by the presence of a… compared with gnRHa daily injection (moderate certainty).

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
OR 0.96 [0.75, 1.23]
11 studies · 1259 participants
Moderate

GnRHa depot vs GnRHa daily injection

OHSS · women undergoing pituitary suppression in assisted reproduction

GnRHa depot showed no clear difference in OHSS incidence rates compared with gnRHa daily injection (low certainty).

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
OR 0.84 [0.29, 2.42]
5 studies · 570 participants
Low

GnRHa depot vs GnRHa daily injection

Miscarriage · women undergoing pituitary suppression in assisted reproduction

GnRHa depot showed no clear difference in miscarriage rates compared with gnRHa daily injection (low certainty).

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
OR 1.16 [0.7, 1.94]
9 studies · 512 participants
Low

GnRHa depot vs GnRHa daily injection

Number of oocytes retrieved · women undergoing pituitary suppression in assisted reproduction

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1142 participants
Low

GnRHa depot vs GnRHa daily injection

Multiple pregnancy rate · women undergoing pituitary suppression in assisted reproduction

GnRHa depot showed no clear difference in multiple pregnancy rates compared with gnRHa daily injection (low certainty).

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
OR 1.1 [0.49, 2.46]
4 studies · 132 participants
Low

GnRHa depot vs GnRHa daily injection

Number of gonadotropin (FSH) units employed · women undergoing pituitary suppression in assisted reproduction

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1043 participants
Low

Different doses of GnRHa depot vs GnRHa daily injection

Number of days of gonadotrophin treatment ‐ half dose · women undergoing pituitary suppression in assisted reproduction

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 507 participants
Low

Different doses of GnRHa depot vs GnRHa daily injection

Number of days of gonadotrophin treatment ‐ full dose · women undergoing pituitary suppression in assisted reproduction

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 526 participants
Low

Different doses of GnRHa depot vs GnRHa daily injection

Number of gonadotrophin (FSH) units employed ‐ half dose · women undergoing pituitary suppression in assisted reproduction

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 616 participants
Very low

Different doses of GnRHa depot vs GnRHa daily injection

Number of gonadotrophin (FSH) units employed ‐ full dose · women undergoing pituitary suppression in assisted reproduction

1 finding from 1 review

Depot versus daily administration of gonadotrophin‐releasing hormone agonist protocols for pituitary down regulation… 2013 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 527 participants
Low