Findings

What do systematic reviews say?

4 questions · 4 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 50%Low 2 · 50%Moderate 0 · 0%High 0 · 0%

GnRH agonists vs GnRH antagonists

Miscarriage · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

GnRH agonists showed no clear difference in miscarriage rate compared with gnRH antagonists (low certainty).

1 finding from 1 review

Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
OR 0.75 [0.38, 1.49]
1 study · 473 participants
Low

GnRH agonists vs control

Miscarriage · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

GnRH agonists showed no clear difference in miscarriage rate compared with control (low certainty).

1 finding from 1 review

Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
OR 0.85 [0.36, 2]
4 studies · 828 participants
Low

GnRH agonists vs placebo

Miscarriage · women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes

It is very uncertain whether among different GnRH agonists changes miscarriage rate compared with placebo (very low certainty).

1 finding from 1 review

Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes 2020 · Cochrane Headline outcomes only
OR 1.33 [0.36, 4.87]
1 study · 68 participants
Very low

Gonadotropins with GnRH agonists vs gonadotropins alone

Miscarriage · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether gonadotropins with GnRH agonists changes miscarriage rate per couple compared with gonadotropins alone (very low certainty).

1 finding from 1 review

Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility 2021 · Cochrane Headline outcomes only
OR 2.07 [0.18, 24.15]
1 study · 60 participants
Very low