Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 71.4%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%

Side effects ‐ hot flushes · women with symptomatic endometriosis

It is very uncertain whether gestrinone changes side effects: hot flushes compared with danazol (very low certainty).

1 finding from 1 review

Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
OR 0.79 [0.5, 1.26]
2 studies · 302 participants
Very low

Adverse effects: acne · women with symptomatic endometriosis

Gestrinone showed no clear difference in side effects: acne compared with danazol (low certainty).

1 finding from 1 review

Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
OR 1.45 [0.9, 2.33]
2 studies · 302 participants
Low

Pelvic pain · women with symptomatic endometriosis

It is very uncertain whether gestrinone changes pelvic pain: none or mild compared with danazol (very low certainty).

1 finding from 1 review

Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
OR 0.71 [0.33, 1.56]
2 studies · 230 participants
Very low

Dysmenorrhoea: none or mild · women with symptomatic endometriosis

It is very uncertain whether gestrinone changes dysmenorrhoea: none or mild compared with danazol (very low certainty).

1 finding from 1 review

Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
OR 0.72 [0.39, 1.33]
2 studies · 214 participants
Very low

Dyspareunia: none or mild · women with symptomatic endometriosis

It is very uncertain whether gestrinone changes dyspareunia: none or mild compared with danazol (very low certainty).

1 finding from 1 review

Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
OR 0.83 [0.37, 1.86]
2 studies · 222 participants
Very low

Side effects ‐ hirsutism · women with symptomatic endometriosis

It is very uncertain whether gestrinone changes side effects: hirsutism compared with danazol (very low certainty).

1 finding from 1 review

Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
OR 2.63 [1.6, 4.32]
2 studies · 302 participants
Very low

Decreased breast size · women with symptomatic endometriosis

Gestrinone may leads to lower decreased breast size compared with danazol (low certainty).

1 finding from 1 review

Progesterone receptor modulators for endometriosis 2017 · Cochrane Headline outcomes only
OR 0.62 [0.38, 0.98]
2 studies · 302 participants
Low