What do systematic reviews say?

6 questions · 12 findings · 1 reviews · Dental caries

No studies found 0 · 0%GRADE not reported 12 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Osteoporosis with pathological fracture · European GWAS participants

The SVMR Weighted Median interval included the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 0.985 [0.846, 1.146]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 1.003 [0.874, 1.151]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 0.953 [0.813, 1.117]
376746 participants
GRADE not reported

Osteoporosis with pathological fracture · European-ancestry adults

Genetically predicted periodontitis had no causal effect on osteoporosis with pathological fracture (single-variable MR, OR 1.003).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 1.003 [0.875, 1.150]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for DMFS
OR 1.003 [0.546, 1.842]
376746 participants
GRADE not reported

Osteoporosis with pathological fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.002 [0.867, 1.158]
376746 participants
GRADE not reported

Postmenopausal osteoporosis with pathological fracture · European GWAS participants