What do systematic reviews say?

9 questions · 19 findings · 1 reviews · Dental caries

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No studies found 0 · 0%GRADE not reported 19 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Osteoporosis · European GWAS participants

The SVMR MR-Egger interval included the null.

4 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 1.001 [0.918, 1.093]
483725 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 0.998 [0.934, 1.067]
483725 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 1.002 [0.925, 1.086]
483725 participants
GRADE not reported

Show 1 more finding

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR IVW
OR 0.998 [0.933, 1.067]
483725 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Osteoporosis · European-ancestry adults

Genetically predicted periodontitis had no causal effect on osteoporosis (multivariable MR, OR 1.000).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for DMFS
OR 1.000 [0.937, 1.067]
483725 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 0.998 [0.933, 1.067]
483725 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS

Osteoporosis · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.005 [0.940, 1.074]
483725 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Osteoporosis with pathological fracture · European GWAS participants

The SVMR Weighted Median interval included the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 0.985 [0.846, 1.146]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 1.003 [0.874, 1.151]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 0.953 [0.813, 1.117]
376746 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Osteoporosis with pathological fracture · European-ancestry adults

Genetically predicted periodontitis had no causal effect on osteoporosis with pathological fracture (single-variable MR, OR 1.003).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 1.003 [0.875, 1.150]
376746 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for DMFS
OR 1.003 [0.546, 1.842]
376746 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS

Osteoporosis with pathological fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.002 [0.867, 1.158]
376746 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability, adjusted for DMFS

Postmenopausal osteoporosis with pathological fracture · European GWAS participants

The MVMR MR-Egger interval included the null.

1 finding from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · MVMR MR-Egger
OR 1.012 [0.858, 1.193]
281786 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Postmenopausal osteoporosis with pathological fracture · European GWAS participants

The SVMR Weighted Median interval included the null.

3 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Weighted Median
OR 0.979 [0.826, 1.159]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR Maximum Likelihood
OR 1.014 [0.872, 1.179]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Summary-level GWAS · SVMR MR-Egger
OR 0.934 [0.786, 1.111]
281786 participants
GRADE not reported

Genetically predicted periodontitis vs Lower genetically predicted periodontitis liability

Postmenopausal osteoporosis with pathological fracture · Postmenopausal women (European ancestry)

Genetically predicted periodontitis had no causal effect on postmenopausal osteoporosis with pathological fracture (single-variable MR, OR 1.014).

2 findings from 1 review

From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · SVMR (IVW), total causal effect
OR 1.014 [0.857, 1.199]
281786 participants
GRADE not reported
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomes
Lifelong genetic liability · European-ancestry population (two-sample MR: GLIDE exposures; FinnGen osteoporosis/fractures; GeFOS BMD) · MVMR (IVW), adjusted for DMFS
OR 1.016 [0.867, 1.191]
281786 participants
GRADE not reported