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What do systematic reviews say?

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Evidence found and GRADE certainty

4 questions · 5 findings · 3 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 20%Low 0 · 0%Moderate 3 · 60%High 1 · 20%

Gefitinib vs chemotherapy alone

Overall survival (OS) · People with advanced non‐small cell lung cancer

Gefitinib showed no clear difference in overall survival (OS) compared with chemotherapy (moderate certainty).

2 findings from 1 review

Gefitinib vs pemetrexed + carboplatin with pemetrexed maintenance

Overall survival · EGFR M+ patients with NSCLC

Gefitinib showed no clear difference in overall survival compared with pemetrexed + carboplatin with pemetrexed maintenance (moderate certainty).

1 finding from 1 review

Tyrosine kinase inhibitor (erlotinib, gefitinib or lapatinib) plus standard therapy (radiotherapy or chemoradiotherapy) vs Standard therapy alone (radiotherapy or chemoradiotherapy)

Overall survival · People with squamous cell carcinoma of the oral cavity or oropharynx

It is very uncertain whether tyrosine kinase inhibitor (erlotinib, gefitinib or lapatinib) plus… changes overall survival compared with standard therapy alone (radiotherapy or chemoradiotherapy) (very low certainty).

1 finding from 1 review