Findings

What do systematic reviews say?

18 questions · 18 findings · 3 reviews

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No studies found 5 · 27.8%GRADE not reported 0 · 0%Very low 4 · 22.2%Low 3 · 16.7%Moderate 6 · 33.3%High 0 · 0%

Fresh frozen plasma vs no plasma

Short‐term mortality (up to 30 days) · Neonates, children and adults undergoing cardiovascular surgery

1 finding from 1 review

Fresh frozen plasma for cardiovascular surgery 2015 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 287 participants
Very low

Fresh frozen plasma vs no plasma

Blood loss in first 24 hours (neonates and paediatric cases) · Neonates, children and adults undergoing cardiovascular surgery

1 finding from 1 review

Fresh frozen plasma for cardiovascular surgery 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 138 participants
Low

Fresh frozen plasma vs no plasma

Red cell transfusion requirement in first 24 hours (neonates and paediatric cases) · Neonates, children and adults undergoing cardiovascular surgery

1 finding from 1 review

Fresh frozen plasma for cardiovascular surgery 2015 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 110 participants
Low

Fresh frozen plasma vs no plasma

Number of participants receiving a red cell transfusion (total) · Neonates, children and adults undergoing cardiovascular surgery

Fresh frozen plasma probably leads to higher number of patients receiving a red cell transfusion compared with no plasma (moderate certainty).

1 finding from 1 review

Fresh frozen plasma for cardiovascular surgery 2015 · Cochrane Headline outcomes only
OR 2.57 [1.3, 5.08]
4 studies · 222 participants
Moderate

Fresh frozen plasma vs no plasma

Measurement of prothrombin time within 2 hours of infusion · Neonates, children and adults undergoing cardiovascular surgery

1 finding from 1 review

Fresh frozen plasma for cardiovascular surgery 2015 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 210 participants
Moderate

Fresh frozen plasma vs no plasma

Resource use: need for return to theatre · Neonates, children and adults undergoing cardiovascular surgery

Fresh frozen plasma showed no clear difference in resource use: need for return to theatre compared with no plasma (moderate certainty).

1 finding from 1 review

Fresh frozen plasma for cardiovascular surgery 2015 · Cochrane Headline outcomes only
OR 0.81 [0.26, 2.57]
7 studies · 398 participants
Moderate

Albumin and fresh frozen plasma vs crystalloid

All‐cause mortality (at end of

Albumin and fresh frozen plasma showed no clear difference in all‐cause mortality (at end of compared with crystalloid (moderate certainty).

1 finding from 1 review

Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
RR 0.98 [0.92, 1.06]
20 studies · 13047 participants
Moderate

Albumin and fresh frozen plasma vs crystalloid

All‐cause mortality (within 90 days)

Albumin and fresh frozen plasma showed no clear difference in all‐cause mortality (within 90 days) compared with crystalloid (moderate certainty).

1 finding from 1 review

Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
RR 0.98 [0.92, 1.04]
10 studies · 12492 participants
Moderate

Albumin and fresh frozen plasma vs crystalloid

All‐cause mortality (within 30 days)

Albumin and fresh frozen plasma showed no clear difference in all‐cause mortality (within 30 days) compared with crystalloid (moderate certainty).

1 finding from 1 review

Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
RR 0.99 [0.93, 1.06]
10 studies · 12506 participants
Moderate

Albumin and fresh frozen plasma vs crystalloid

Transfusion of blood products

It is very uncertain whether albumin and fresh frozen plasma changes transfusion of blood products compared with crystalloid (very low certainty).

1 finding from 1 review

Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
RR 1.31 [0.95, 1.8]
3 studies · 290 participants
Very low

Albumin and fresh frozen plasma vs crystalloid

Renal replacement therapy

Albumin and fresh frozen plasma showed no clear difference in renal replacement therapy compared with crystalloid (low certainty).

1 finding from 1 review

Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
RR 1.11 [0.96, 1.27]
2 studies · 3028 participants
Low

Albumin and fresh frozen plasma vs crystalloid

Adverse events

1 finding from 1 review

Colloids versus crystalloids for fluid resuscitation in critically ill people 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Fresh frozen plasma vs no treatment

Incidence of hepatic veno‐occlusive disease ( · Patients undergoing stem cell transplant with malignant and non‐malignant diseases

It is very uncertain whether summary of findings: Fresh frozen plasma changes incidence of hepatic veno‐occlusive disease ( compared with no treatment (very low certainty).

1 finding from 1 review

Interventions for prophylaxis of hepatic veno‐occlusive disease in people undergoing haematopoietic stem cell… 2015 · Cochrane Headline outcomes only
RR 0.66 [0.2, 2.17]
2 studies · 383 participants
Very low

Fresh frozen plasma vs no treatment

Overall survival · Patients undergoing stem cell transplant with malignant and non‐malignant diseases