Summary of findings: Folic acid vs placebo
GI side effects (ie, incidence of nausea, vomiting, abdominal pain) · Patients receiving methotrexate for rheumatoid arthritis
Folic acid showed no clear difference in GI side effects (ie, incidence of nausea, vomiting, abdominal pain) compared with placebo (moderate certainty).
1 finding from 1 review
- Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis 2013 · Cochrane Headline outcomes onlyRR 0.76 [0.57, 1.01]3 studies · 355 participantsModerate