Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 5 · 100%High 0 · 0%

Failure to respond (reduction ≥ 50% on HDRS) · patients with depression

Fluoxetine probably leads to higher failure to respond (reduction ≥ 50% on HDRS) compared with sertraline (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.37 [1.08, 1.74]
6 studies · 1188 participants
Moderate

Endpoint score (HDRS or MADRS) · patients with depression

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1160 participants
Moderate

Failure to complete ‐ total ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ total ‐ compared with sertraline (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.17 [0.93, 1.49]
9 studies · 1591 participants
Moderate

Failure to complete ‐ inefficacy ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ inefficacy ‐ compared with sertraline (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.09 [0.68, 1.77]
5 studies · 1056 participants
Moderate

Failure to complete ‐ side effects ‐ · patients with depression

Fluoxetine showed no clear difference in failure to complete ‐ side effects ‐ compared with sertraline (moderate certainty).

1 finding from 1 review

Fluoxetine versus other types of pharmacotherapy for depression 2013 · Cochrane Headline outcomes only
OR 1.25 [0.92, 1.7]
9 studies · 1591 participants
Moderate