Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

166 questions · 167 findings · 5 reviews

No studies found 12 · 7.2%GRADE not reported 13 · 7.8%Very low 17 · 10.2%Low 30 · 18%Moderate 91 · 54.5%High 4 · 2.4%

Fluoxetine vs placebo

Any adverse event (N) · overweight or obese adults

Summary of findings: fluoxetine showed no clear difference in any adverse event (N) compared with placebo (low certainty).

1 finding from 1 review

Fluoxetine vs placebo

Morbidity: depression (N) · overweight or obese adults

It is very uncertain whether summary of findings: fluoxetine changes morbidity: depression (N) compared with placebo (very low certainty).

1 finding from 1 review

Augmentation of current antidepressant (fluoxetine 20 mg/d) with mianserin (60 mg/d) vs placebo plus antidepressant

Leaving the study early · treatment‐resistant depression in adults

Augmentation of current antidepressant (fluoxetine 20 mg/d) with… showed no clear difference in dropouts compared with augmentation of current antidepressant (fluoxetine 20 mg/d) with… (low certainty).

1 finding from 1 review

Augmentation of current antidepressant (fluoxetine 20 mg/d) with mianserin (60 mg/d) vs placebo plus antidepressant

Proportions of participants responding to treatment ≥ 50% reduction in depression score from baseline to end of treatment. A larger RR indicates greater response to treatment in the SAMe group · treatment‐resistant depression in adults

Augmentation of current antidepressant (fluoxetine 20 mg/d) with… may leads to higher response (≥ 50% reduction in HAM‐D score) compared with augmentation of current antidepressant (fluoxetine 20 mg/d) with… (low certainty).

1 finding from 1 review