Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Airways

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%

Fluoroquinolones vs amoxicillin

Exacerbations · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Fluoroquinolones vs amoxicillin

Serious adverse events · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 83 participants
Low

Fluoroquinolones vs amoxicillin

Response rate ‐ treatment failure · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

Fluoroquinolones may leads to lower response rate ‐ treatment failure compared with amoxicillin (low certainty).

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
OR 0.07 [0.01, 0.32]
2 studies · 83 participants
Low

Fluoroquinolones vs amoxicillin

Response rate ‐ microbiological response · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

Fluoroquinolones may leads to higher response rate ‐ microbiological response compared with amoxicillin (low certainty).

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
Peto OR 20.09 [2.83, 142.59]
1 study · 16 participants
Low

Fluoroquinolones vs amoxicillin

Response rate ‐ improvement in sputum purulence (excellent) · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

It is very uncertain whether fluoroquinolones changes response rate ‐ improvement in sputum purulence (excellent) compared with amoxicillin (very low certainty).

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
OR 2.35 [0.96, 5.72]
2 studies · 83 participants
Very low

Fluoroquinolones vs amoxicillin

Deaths · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 83 participants
Low

Fluoroquinolones vs amoxicillin

Quality of life · adults aged 18 years and above with diagnosis of non‐cystic fibrosis bronchiectasis

The review found no eligible studies for this question.

1 finding from 1 review

Head‐to‐head trials of antibiotics for bronchiectasis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found