Number of visits to the dentist for repair of sealant or fluoride varnish application · Children and adolescents (general population, aged under 20 years)
The review found no eligible studies for this question.
1 finding from 1 review
Time taken to apply pit and fissure sealant or fluoride varnish · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less
Fluoride varnish showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride toothpaste; GRADE not reported.
1 finding from 1 review
RR 1.28 [0.37, 4.41]
1 study
GRADE not reported
Proportion of children developing new caries (deciduous) · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment in permanent teeth · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment in permanent teeth · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment (dfs), deciduous teeth · Children and adolescents aged 16 years or less
1 finding from 1 review
Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less
Fluoride varnish showed no clear difference in unacceptability of treatment (drop-outs) compared with fluoride mouthrinse; GRADE not reported.
1 finding from 1 review
RR 1.19 [0.86, 1.65]
2 studies
GRADE not reported
Proportion of children developing new caries (deciduous) · Children and adolescents aged 16 years or less
Fluoride varnish showed no clear difference in proportion of children developing one or more new caries… compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Adverse effects / specific side effects (oral allergic reactions, mucosal irritation, adverse symptoms such as nausea, gagging, vomiting) · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment in primary/deciduous teeth: decayed, (extraction indicated/missing) and filled teeth d(e/m)ft (prevented fraction) · Children and adolescents aged 16 years or less
1 finding from 1 review
Proportion of children developing new caries (permanent) · Children and adolescents aged 16 years or less
Fluoride varnish showed no clear difference in proportion of children developing one or more new caries (permanent… compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
Caries increment on permanent whole teeth (D(M)FT), prevented fraction · Children and adolescents aged 16 years or less
1 finding from 1 review
PF 0.44 [0.11, 0.76]
5 studies
GRADE not reported
Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less
1 finding from 1 review
Caries increment on primary (deciduous) tooth surfaces (d(e/m)fs), prevented fraction · Children and adolescents aged 16 years or less
1 finding from 1 review
Fluorosis (percentage prevalence in permanent teeth) · Children exposed to topical fluoride when under 6 years old; fluorosis assessed in permanent teeth at 6 to 18 years
Fluoride varnish applied before 4 years of age may leads to higher fluorosis (percentage prevalence in permanent teeth) compared with no fluoride varnish application (low certainty).
1 finding from 1 review
Progression of dentinal carious lesions into enamel or dentine · Children and adolescents (general population, aged under 20 years)
The review found no eligible studies for this question.
1 finding from 1 review
Changes in decayed, missing and filled (DMF) figures at whole-mouth level · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
It is very uncertain whether resin-based fissure sealant plus fluoride varnish changes dentine caries in permanent molars (yes/no) compared with fluoride varnish alone (very low certainty).
1 finding from 1 review
Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less
Fluoride varnish combined with fluoride toothpaste showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride varnish alone; GRADE not reported.
1 finding from 1 review