Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Dental caries

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No studies found 1 · 14.3%GRADE not reported 6 · 85.7%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Fluoride gel combined with fluoride mouthrinse vs Fluoride mouthrinse

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Nearest to 3 years
PF 0.02 [-0.20, 0.24]
1 study · 252 participants
GRADE not reported

Fluoride gel combined with fluoride mouthrinse vs Fluoride gel

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride gel combined with fluoride mouthrinse showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride gel alone; GRADE not reported.

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
RR 1.00 [0.72, 1.40]
1 study · 344 participants
GRADE not reported

Fluoride gel combined with fluoride mouthrinse vs Fluoride gel

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Nearest to 3 years
PF 0.23 [0.04, 0.43]
2 studies · 497 participants
GRADE not reported

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

Adverse effects (tooth staining and other side effects) · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Adverse-effect data scarcely reported: a stain score in one trial and 'any side effects' in one trial without complete or useable data (stated 'no side effects observed in both groups'). No useful information on tooth…
Studies not reported
GRADE not reported

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

Adverse effects: dental fluorosis · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Fluorosis data have not been reported in any of the trials.
0 studies
No studies found

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

Unacceptability of treatment (drop-outs / leaving study early) · Children and adolescents aged 16 years or less

Fluoride mouthrinse, gel or varnish combined with fluoride… showed no clear difference in unacceptability of treatment (drop-outs / leaving study early) compared with fluoride toothpaste alone; GRADE not reported.

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
RR 1.06 [0.93, 1.22]
5 studies · 1998 participants
GRADE not reported

Fluoride mouthrinse, gel or varnish combined with fluoride toothpaste (any combined regimen) vs Fluoride toothpaste alone

Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or less

1 finding from 1 review

Combinations of topical fluoride (toothpastes, mouthrinses, gels, varnishes) versus single topical fluoride for… 2004 · Cochrane All outcomes
Nearest to 3 years
PF 0.10 [0.02, 0.17]
9 studies · 4026 participants
GRADE not reported