Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

27 questions · 28 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 3 · 10.7%Very low 11 · 39.3%Low 14 · 50%Moderate 0 · 0%High 0 · 0%

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – all fish oil LE vs non‐fish oil LE (combined subgroups) · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – all fish oil LE… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (any definition: low and unclear risk of bias studies) – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (any definition: low and unclear risk of bias… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (any definition): combined subgroups (all studies) – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/cholestasis (any definition): combined subgroups (all studies)… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

ROP ≥ stage 3 or requiring surgery – all fish oil LE vs non‐fish oil LE · Parenterally fed preterm infants

It is very uncertain whether fish oil lipid emulsion (LE) changes ROP ≥ stage 3 or requiring surgery – all fish oil LE vs non‐fish oil… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Resolution of PNALD/ cholestasis (conjugated bilirubin < 2 mg/dL) Pure F‐LE vs Intralipid · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes resolution of PNALD/ cholestasis (conjugated bilirubin < 2 mg/dL)… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs another fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE compared with another fish oil LE (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – pure F‐LE vs S‐LE · parenterally fed preterm infants with surgical conditions

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review