Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

69 questions · 70 findings · 7 reviews

No studies found 5 · 7.1%GRADE not reported 7 · 10%Very low 30 · 42.9%Low 26 · 37.1%Moderate 2 · 2.9%High 0 · 0%

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE · parenterally fed term and late preterm infants

It is very uncertain whether fish oil LE changes PNALD/cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs another fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – MOFS‐LE vs MFS‐LE compared with another fish oil LE (low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – pure F‐LE vs S‐LE · parenterally fed preterm infants with surgical conditions

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Resolution of PNALD/ cholestasis (conjugated bilirubin < 2 mg/dL) Pure F‐LE vs Intralipid · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes resolution of PNALD/ cholestasis (conjugated bilirubin < 2 mg/dL)… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes PNALD/ cholestasis (any definition) MOFS‐LE vs S‐LE Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review