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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 33.3%Moderate 1 · 16.7%High 3 · 50%

Febuxostat 80 mg/day vs placebo

Acute gout attacks · people with chronic gout

Febuxostat 80 mg/day showed no clear difference in incidence of gout flares compared with placebo (low certainty).

1 finding from 1 review

Febuxostat 40 mg/day vs placebo

Acute gout attacks · people with chronic gout

Febuxostat 40 mg/day showed no clear difference in incidence of gout flares compared with placebo (low certainty).

1 finding from 1 review

Febuxostat 120 mg/day vs placebo

Acute gout attacks · patients with chronic cout

Febuxostat 120 mg/day probably leads to higher incidence of gout flares compared with placebo (moderate certainty).

1 finding from 1 review