Acute adverse events
It is very uncertain whether extended‐field chemoradiotherapy changes acute adverse events compared with pelvic chemoradiotherapy (very low certainty).
1 finding from 1 review
Late adverse events
It is very uncertain whether extended‐field chemoradiotherapy changes late adverse events compared with pelvic chemoradiotherapy (very low certainty).
1 finding from 1 review
VTE‐related mortality4 · patients with unprovoked venous thromboembolism
Extended prophylaxis showed no clear difference in VTE‐related mortalitya compared with placebo (low certainty).
1 finding from 1 review
Recurrent VTEc · patients with unprovoked venous thromboembolism
Extended prophylaxis showed no clear difference in recurrent VTEc compared with placebo (moderate certainty).
1 finding from 1 review
Major bleedinge · patients with unprovoked venous thromboembolism
Extended prophylaxis showed no clear difference in major bleedinge compared with placebo (low certainty).
1 finding from 1 review
All‐cause mortalityg · patients with unprovoked venous thromboembolism
Extended prophylaxis showed no clear difference in all‐cause mortalityg compared with placebo (moderate certainty).
1 finding from 1 review
Clinically relevant non‐major bleeding Treatment duration 28 ‐ 42 days · patients with unprovoked venous thromboembolism
Extended prophylaxis showed no clear difference in clinically relevant non‐major bleedingh compared with placebo (low certainty).
1 finding from 1 review
Strokei · patients with unprovoked venous thromboembolism
Extended prophylaxis showed no clear difference in strokei compared with placebo (low certainty).
1 finding from 1 review
Myocardial infarction · patients with unprovoked venous thromboembolism
Extended prophylaxis showed no clear difference in myocardial infarction compared with placebo (low certainty).
1 finding from 1 review
HIV transmission at 6 months among those whose HIV diagnostic testing was negative within 96 hours of birth · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission at 6 months among those whose HIV diagnostic… compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).
1 finding from 1 review
Infant Mortality at 6 Months · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infant Mortality at 6 months compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).
1 finding from 1 review
HIV Transmission or Death at 6 months among those whose HIV diagnostic testing was negative within 96 hours of birth · HIV‐infected mothers and their breastfeeding infants
It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes HIV Transmission or Death at 6 months among those whose HIV… compared with an extended ZDV/3TC/ABC administered to mothers (very low certainty).
1 finding from 1 review
Infant Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in infants with Grade 3/4 Severe Adverse Events compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).
1 finding from 1 review
Maternal mortality ‐ not reported · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in maternal Mortality at 6 months compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).
1 finding from 1 review
Maternal Grade 3/4 Severe Adverse Events · HIV‐infected mothers and their breastfeeding infants
An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in mothers with any Grade 3/4 Severe Adverse Event compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).
1 finding from 1 review
Mothers with Severe Adverse Events Requiring Treatment Modification · HIV‐infected mothers and their breastfeeding infants
It is very uncertain whether an extended ZDV/3TC/LPV/r regimen administered to mothers changes mothers with Severe Adverse Events Requiring Treatment Modification compared with an extended ZDV/3TC/ABC administered to mothers (very low certainty).
1 finding from 1 review
Quantity of drinking (g/week) at 12 months · people with hazardous or harmful alcohol consumption
1 finding from 1 review
Frequency of binge drinking (no. binges/wk) at 12 months ‐ not measured · people with hazardous or harmful alcohol consumption
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Frequency of drinking (no. days drinking/week) at 12 months · people with hazardous or harmful alcohol consumption
1 finding from 1 review
Drinking Intensity · people with hazardous or harmful alcohol consumption
1 finding from 1 review