Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

10 questions · 10 findings · 2 reviews

No studies found 4 · 40%GRADE not reported 1 · 10%Very low 4 · 40%Low 1 · 10%Moderate 0 · 0%High 0 · 0%

Evening vs morning dosing regimen

All‐cause mortality · adults with primary (essential) hypertension whose systolic or diastolic (or both) blood pressure levels were 130/80 mmHg or greater

It is very uncertain whether evening changes all‐cause mortality compared with morning dosing regimen (very low certainty).

1 finding from 1 review

Evening vs morning dosing regimen

Serious adverse events · adults with primary (essential) hypertension whose systolic or diastolic (or both) blood pressure levels were 130/80 mmHg or greater

It is very uncertain whether evening changes serious adverse events compared with morning dosing regimen (very low certainty).

1 finding from 1 review

Evening vs morning dosing regimen

Overall adverse events · adults with primary (essential) hypertension whose systolic or diastolic (or both) blood pressure levels were 130/80 mmHg or greater

It is very uncertain whether evening changes overall adverse events compared with morning dosing regimen (very low certainty).

1 finding from 1 review

Evening vs morning dosing regimen

Withdrawals due to adverse events · adults with primary (essential) hypertension whose systolic or diastolic (or both) blood pressure levels were 130/80 mmHg or greater

It is very uncertain whether evening changes withdrawals from treatment due to adverse events compared with morning dosing regimen (very low certainty).

1 finding from 1 review

Summary of findings: Evening RT vs morning RT

Acute and late GI toxicity (grade 2+) · People undergoing radiotherapy for uterine cervical cancer

Summary of findings: Evening RT may leads to lower acute and late GI toxicity (grade 2+) compared with morning RT (low certainty).

1 finding from 1 review