Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Pregnancy and Childbirth

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 3 · 42.9%Moderate 3 · 42.9%High 0 · 0%

Ergot alkaloids (any route of administration) vs no uterotonic agents

Mean blood loss (mL) visual estimation · women in the third stage of labour

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 2718 participants
Moderate

Ergot alkaloids (any route of administration) vs no uterotonic agents

Maternal blood loss of 500 mL or greater · women in the third stage of labour

Ergot alkaloids (any route of administration) may leads to lower PPH (estimated or measured blood loss of at least 500 mL) visual… compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.52 [0.28, 0.94]
5 studies · 3708 participants
Low

Ergot alkaloids (any route of administration) vs no uterotonic agents

Severe PPH (≥ 1000 mL) · women in the third stage of labour

It is very uncertain whether ergot alkaloids (any route of administration) changes severe PPH (estimated or measured blood loss of at least 1000 mL)… compared with no uterotonic agents (very low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.32 [0.04, 2.59]
2 studies · 1718 participants
Very low

Ergot alkaloids (any route of administration) vs no uterotonic agents

Haemoglobin (g/dL) · women in the third stage of labour

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1429 participants
Moderate

Ergot alkaloids (any route of administration) vs no uterotonic agents

Use of therapeutic uterotonics · women in the third stage of labour

Ergot alkaloids (any route of administration) may leads to lower use of therapeutic uterotonics compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 0.37 [0.15, 0.9]
3 studies · 2698 participants
Low

Ergot alkaloids (any route of administration) vs no uterotonic agents

Elevation of blood pressure · women in the third stage of labour

Ergot alkaloids (any route of administration) may leads to higher elevation of blood pressure compared with no uterotonic agents (low certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 2.6 [1.03, 6.57]
3 studies · 2559 participants
Low

Ergot alkaloids (any route of administration) vs no uterotonic agents

Pain after birth requiring analgesia (not prespecified) · women in the third stage of labour

Ergot alkaloids (any route of administration) probably leads to higher pain after birth requiring analgesia (not prespecified) compared with no uterotonic agents (moderate certainty).

1 finding from 1 review

Prophylactic use of ergot alkaloids in the third stage of labour 2018 · Cochrane Headline outcomes only
RR 2.53 [1.34, 4.78]
1 study · 1429 participants
Moderate