What do systematic reviews say?

Epinephrine vs placebo

Epinephrine probably leads to lower admissions at enrollment or < 24 hours (outpatients only) compared with placebo (moderate certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 0.67 [0.5, 0.89]
  5 studies · 995 participants
  Moderate

Epinephrine vs steroids

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with steroid (moderate certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 1.08 [0.77, 1.52]
  1 study · 399 participants
  Moderate

Epinephrine vs placebo

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with placebo (low certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 0.81 [0.63, 1.03]
  3 studies · 875 participants
  Low

Epinephrine vs salbutamol/albuterol

Epinephrine showed no clear difference in admissions at enrollment or < 24 hours (outpatients only) compared with salbutamol/albuterol (moderate certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 0.67 [0.41, 1.09]
  7 studies · 444 participants
  Moderate

Epinephrine vs salbutamol/albuterol

Epinephrine showed no clear difference in admissions overall up to 7 days (outpatients only) compared with salbutamol/albuterol (moderate certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 1.05 [0.71, 1.54]
  2 studies · 212 participants
  Moderate

Epinephrine vs steroids

Epinephrine showed no clear difference in admissions (outpatients only) compared with steroid (moderate certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 1.12 [0.66, 1.88]
  2 studies · 444 participants
  Moderate

Epinephrine and steroid vs placebo

Epinephrine and steroid showed no clear difference in admissions at enrollment or < 24 hours (outpatients only) compared with placebo (low certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 0.64 [0.4, 1.04]
  1 study · 401 participants
  Low

Epinephrine and steroid vs placebo

Epinephrine and steroid may leads to lower admissions overall up to 7 days (outpatients only) compared with placebo (low certainty).

• Epinephrine for bronchiolitis 2011 · Cochrane Headline outcomes only
  RR 0.64 [0.44, 0.95]
  1 study · 400 participants
  Low

Glucocorticoid and epinephrine vs placebo: summary of findings

• Glucocorticoids for acute viral bronchiolitis in infants and young children 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 400 participants
  Low
• Glucocorticoids for acute viral bronchiolitis in infants and young children 2013 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 400 participants
  Low